Characterization of Wild Blueberry Polyphenols Bioavailability and Kinetic Profile Over 24-hour Period

Completed · Not applicable · Has a placebo group

Conditions studied: Overweight, Obese, Healthy

In brief

Primary objective is to characterize the relative bioavailability and kinetic profile of wild blueberry polyphenols over 24-hours period. Secondary objective is to examine the relationship between bioavailability and kinetic profile of wild blueberry polyphenols on markers of chronic diseases.

Key facts

Study ID

NCT02167555

Run by

Clinical Nutrition Research Center, Illinois Institute of Technology

People needed

12

Starts

2014-06-01

Expected to finish

2016-01-19

Last updated by the study team

2021-01-26

Who can join

Age: 20 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 20-45 years of age
• Body Mass Index (BMI) range from 25 to 33 kg/m2
• Nonsmoker
• No clinical evidence of cardiovascular, metabolic, respiratory, renal, gastrointestinal or hepatic disease
• Not taking any medications that would interfere with outcomes of the study, i.e. lipid lowering medications, anti-inflammatory drugs, dietary supplements, etc…
• Able to provide informed consent
• Able to comply and perform the procedures requested by the protocol
• Weight stable: not gained or lost weight +/- 5 kg in previous 3 months

You may not qualify if…

• Men and women who smoke
• Past smokers: abstinence for minimum 2 years
• Men and women with known or suspected food intolerance, allergies or hypersensitivity
• Men and women known to have/diagnosed with diabetes mellitus
• Men and women who have fasting blood glucose concentrations > 110mg/dL
• Men and women who have uncontrolled blood pressure >120 mmHg/80 mmHg
• Men and women with documented vascular disease, e.g., heart failure, myocardial infarction, stroke, angina, related surgeries, etc...
• Men and women with cancer other than non-melanoma skin cancer in previous 5 years
• Women who are known to be pregnant or who are intending to become pregnant over the course of the study
• Women who are lactating
• Taking medication or dietary supplements that may interfere with the outcomes of the study; e.g., antioxidant supplement, anti-inflammation, lipid lowering medication, blood pressure lowering medication, etc... Subjects may choose to go off dietary supplements (requires 30 days washout); e.g., fish oil, probiotics, etc...
• Men and women who have donated blood within 3 months of the Screening Visit and blood donors/participants for whom participation in this study will result in having donated more than 1500 milliliters of blood in the previous 12 months.
• Men and women who are vegans
• Substance (alcohol or drug) abuse within the last 2 years
• Excessive coffee and tea consumers (> 4 cups/d) and berry consumers (>2 cups fresh/day
• Men and women who do excessive exercise regularly or athlete
• Unstable weight: gained or lost weight +/- 5 kg in previous 3 months
• Women who are taking unstable dose and brand of hormonal contraceptives and/or stable dose and brand less than 6 months.

Where it is running

• Clinical Nutrition Research Center — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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