Postoperative Pain Control Results Using Periarticular Versus Intra-capsular Injection of Bupivacaine Liposome Injectable Suspension in Total Knee Arthroplasty

Completed · Not applicable

Conditions studied: Osteoarthritis, Knee

In brief

The purpose of this study is to determine quantitative and qualitative differences in post-operative pain relief for patients undergoing primary total knee arthroplasty (TKA) who receive administration of a newly approved, long acting local anesthetic branded as ExparelTM (bupivacaine liposome injectable suspension) introduced by one of two different administration methods. Group 1 would receive a predetermined and standardized dose of ExparelTM introduced directly into the joint capsule at the conclusion of the surgery, effectively bathing the joint in anesthetic solution. Group 2 would receive the same predetermined and standardized dose of ExparelTM as a local infiltration anesthetic (LIA) by injecting it into the periarticular tissues in nine (9) standard sites at the conclusion of the surgery.

Key facts

Study ID

NCT02166632

Run by

Broward Health

People needed

50

Starts

2014-04-01

Expected to finish

2016-02-01

Last updated by the study team

2016-02-10

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients must be over the age of 18
• Patients must have a preoperative diagnosis of osteoarthritis of the knee requiring total knee arthroplasty

You may not qualify if…

• Allergy to ExparelTM or certain other local anesthetic agents
• Pregnant females or females who think they may become pregnant
• Markedly abnormal kidney function or renal disease
• History of substance abuse
• History of chronic pain requiring medication
• Had a previous total knee arthroplasty on the same knee which is being replaced (revision total knee arthroplasty)
• Had a previous partial knee arthroplasty, such as a unicompartmental knee arthroplasty on the same knee (also a revision total knee arthroplasty)

Where it is running

• Broward Health Sports Medicine — Fort Lauderdale, Florida, United States

Full record on ClinicalTrials.gov

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