A Study of Galcanezumab (LY2951742) in Participants With Migraine Headache

Completed · Phase 2 · Has a placebo group

Conditions studied: Migraine Headache

In brief

The main purpose of this study is to evaluate whether the study drug known as galcanezumab is safe and effective in the prevention of migraine headaches.

Key facts

Study ID

NCT02163993

Run by

Eli Lilly and Company

People needed

414

Starts

2014-07-07

Expected to finish

2018-02-12

Last updated by the study team

2018-11-23

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participants with a history of migraine of at least 1 year prior to enrollment.
• Migraine onset prior to age 50.

You may not qualify if…

• Current enrollment in, or discontinuation within the last 30 days from, a clinical trial involving any investigational drug or device.
• Current use or any prior exposure to any CGRP antibody, any antibody to the CGRP receptor, or antibody to nerve growth factor (NGF).
• History of migraine subtypes including hemiplegic migraine, ophthalmoplegic migraine, and basilar-type migraine.
• Have a history or presence of other medical illness that indicates a medical problem that would preclude study participation.
• Failure to respond to more than two adequately dosed effective migraine prevention treatments.
• Evidence of significant active psychiatric disease, in the opinion of the investigator.
• Women who are pregnant or nursing.

Where it is running

• Clinical Research Advantage — Gilbert, Arizona, United States
• 21st Century Neurology — Phoenix, Arizona, United States
• Arizona Research Center — Phoenix, Arizona, United States
• Pharmacology Research Institute, Long Beach — Encino, California, United States
• Collaborative Neuroscience Network - CNS — Long Beach, California, United States
• Pharmacology Research Institute, Long Beach — Los Alamitos, California, United States
• Pharmacology Research Institute, Long Beach — Newport Beach, California, United States
• Desert Valley Research — Rancho Mirage, California, United States
• Artemis Institute for Clinical Research — San Diego, California, United States
• Medical Center for Clinical Research — San Diego, California, United States
• San Francisco Clinical Research Center — San Francisco, California, United States
• California Medical Clinic for Headache — Santa Monica, California, United States
• Alpine Clinical Research Center — Boulder, Colorado, United States
• New England Institute for Clinical Research — Stamford, Connecticut, United States
• Avail Clinical Research LLC — DeLand, Florida, United States
• Florida Clinical Research Center LLC — Maitland, Florida, United States
• Renstar Medical Research — Ocala, Florida, United States
• Psychiatric Inst of Florida-Clinical Neuroscience Solutions — Orlando, Florida, United States
• Premiere Research Institute at Palm Beach Neurology — West Palm Beach, Florida, United States
• Otri-Med Corporation — Edgewood, Kentucky, United States
• PharmaSite Research Inc — Baltimore, Maryland, United States
• Boston Clinical Trials Inc — Boston, Massachusetts, United States
• Michigan Head, Pain and Neurological Institute — Ann Arbor, Michigan, United States
• Westside Family Medical Center — Kalamazoo, Michigan, United States
• ClinVest — Springfield, Missouri, United States

Full record on ClinicalTrials.gov

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