Effects of Images Following Beverage Ingestion on Brain Activation
Withdrawn before enrolling · Not applicable
Conditions studied: Obesity
In brief
The primary purpose of this study is to quantify activation of regions of the brain associated with taste, appetite, and reward after viewing high sugar and high fat (HS/HF) images compared to control images following ingestion of (1) an artificially sweetened solution, (2) a sucrose solution, and (3) a tasteless control solution in normal weight vs. obese women. This is a repeated measures study design; hence, data are collected on three days corresponding to the three solutions. Body mass index (BMI) is a between subjects measure. 1. After consuming an artificially sweetened solution and a sucrose solution compared to a tasteless solution, viewing HS/HF food images vs. control images will result in higher activation of taste pathways (frontal operulum and anterior insula (FO/AI)) in the brain. 2. After consumption of a sucrose solution compared to an artificially sweetened solution and a tasteless solution, viewing HS/HF food images vs. control images will result in higher activation of regions of the brain associate with appetite (hypothalamus). 3. After consumption of a sucrose solution compared to an artificially sweetened solution and a tasteless solution, viewing HS/HF food images vs. control images will result in higher activation of regions of the brain associated with reward \[amygdala, anterior cingulate cortex (ACC), Orbitalfrontal Cortex (OFC), and ventral tegmental area (VTA), striatum, insula\] in obese but not normal weight women. After consuming an artificially sweetened solution compared to a tasteless solution, viewing HS/HF images vs. control images will result in no differences in activation of reward pathways of the brain.
Key facts
- Study ID
- NCT02163304
- Run by
- Pennington Biomedical Research Center
- People needed
- 0
- Starts
- 2015-08-01
- Expected to finish
- 2016-12-01
- Last updated by the study team
- 2016-01-11
Who can join
Age: 20 and older, up to 35. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- Female
- 20-35 years old (inclusive)
- Weigh less than 350 lbs
- Weight stable (>±5 kg in the last 6 months).
- Body mass index (BMI) between 20-25 kg/m2 or 30-35 kg/m2.
- Willing to fast for 10 hours prior to examination.
- Right handed.
You may not qualify if…
- Diagnosis (by self report) of diabetes
- Diagnosis (by self report) of neurological condition
- Current or past alcohol or drug abuse problem.
- Smoking
- Have internal metal medical devices including cardiac pacemakers, aortic or cerebral aneurysm clips, artificial heart valves, ferromagnetic implants, shrapnel, wire sutures, joint replacements, bone or joint pins/rods/screws/clips, metal plates, metal fragments in your eye, or non-removable metal jewelry such as rings.
- Unable or unwilling to complete the imaging procedures for the duration of the MRI scan due to claustrophobia or other reason.
Where it is running
- Pennington Biomedical Research Center — Baton Rouge, Louisiana, United States
Full record on ClinicalTrials.gov
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