A Study to Assess Benign Joint Hypermobility Syndrome in Children With a History of Wheezing or Asthma

Completed

Conditions studied: Benign Joint Hypermobility Syndrome, Wheezing, Asthma

In brief

The purpose of this study is to assess benign joint hypermobility syndrome (BJHS) in children with a history of wheezing or asthma. BJHS is a common syndrome of joint and connective tissue laxity without any other rheumatologic disease. This assessment will be performed by using either method below depending upon if the child has a history of wheezing or severe asthma: 1. Determine the correlation, if there is an increased rate of BJHS in children with a history of wheezing as well as if there is an increased history of wheezing in children with BJHS; or 2. Determine asthma control, lung function and asthma exacerbations (a flare up or acute worsening of symptoms) in children with BJHS compared to children with asthma without BJHS, to assess if it BJHS is associated more with children with severe asthma.

Key facts

Study ID

NCT02163096

Run by

University of Louisville

People needed

23

Starts

2014-06-01

Expected to finish

2015-06-01

Last updated by the study team

2016-01-08

Who can join

Age: 6 and older, up to 16. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• All children ages 6-16 with a history of wheezing or asthma

You may not qualify if…

• For subjects with a history of Wheezing: History of chronic lung disease or prematurity, chronic aspiration, congenital anomalies of the upper and lower airway, primary ciliary dyskinesia, cystic fibrosis, history of heart failure, immune deficiency, or any inflammatory arthritis.
• For Subjects with a history of Asthma: current acute respiratory exacerbation, history of chronic lung disease of prematurity, chronic aspiration, congenital anomalies of the upper or lower airway, primary ciliary dyskinesia, cystic fibrosis, restrictive lung disease, history of heart failure, immune deficiency, or inflammatory arthritis.

Where it is running

• University of Louisville - Sam Swope Kosair Charities Centre — Louisville, Kentucky, United States
• University of Louisville Allergy and Immunology — Louisville, Kentucky, United States
• University of Louisville Pediatric Pulmonology — Louisville, Kentucky, United States

Full record on ClinicalTrials.gov

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