Effects of Images Following Long-term Aerobic Exercise on Brain Activation
Withdrawn before enrolling · Not applicable
Conditions studied: Obesity
In brief
The primary purpose of this study is to quantify activation of regions of the brain associated with appetite and reward after viewing high sugar and high fat (HS/HF) images compared to control images following long-term aerobic exercise. 1. After long-term aerobic exercise compared to a no-exercise control group, viewing HS/HF food images vs. control images will result in higher activation of regions of the brain associate with appetite (hypothalamus). 2. After long-term aerobic exercise compared to a no-exercise control group consumption of a sucrose solution compared to an artificially sweetened solution and a tasteless solution, viewing HS/HF food images vs. control images will result in lower activation of regions of the brain associated with reward \[amygdala, anterior cingulate cortex (ACC), Orbitalfrontal Cortex (OFC), and ventral tegmental area (VTA), striatum, insula\] in overweight and obese men and women. Exploratory Aims As exploratory aims, investigators will test a preliminary brain connectivity analysis.
Key facts
- Study ID
- NCT02162524
- Run by
- Pennington Biomedical Research Center
- People needed
- 0
- Starts
- 2014-01-01
- Expected to finish
- 2015-07-01
- Last updated by the study team
- 2016-01-11
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Male or Female
- 18-65 years old (inclusive)
- Weigh less than 350 lbs
- Body mass index (BMI) between 25-43 kg/m2
- Willing to fast for 10 hours prior to examination
- Right handed
You may not qualify if…
- Diagnosis (by self report) of diabetes
- Diagnosis (by self report) of neurological condition
- Current or past alcohol or drug abuse problem
- Smoking
- Have internal metal medical devices including cardiac pacemakers, aortic or cerebral aneurysm clips, artificial heart valves, ferromagnetic implants, shrapnel, wire sutures, joint replacements, bone or joint pins/rods/screws/clips, metal plates, metal fragments in your eye, or non-removable metal jewelry such as rings
- Unable or unwilling to complete the imaging procedures for the duration of the MRI scan due to claustrophobia or other reason
Where it is running
- Pennington Biomedical Research Center — Baton Rouge, Louisiana, United States
Full record on ClinicalTrials.gov
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