Feasibility of Upright Bed Position in ARDS Patients
Completed · Not applicable
Conditions studied: Critical Illness, Acute Respiratory Failure, Adult Syndrome
In brief
Lower lobe atelectasis of the lung is common in Acute Respiratory Distress Syndrome (ARDS) and has the potential to adversely impact lung compliance and intra-pulmonary shunt. The cephalic shift of the diaphragm and dorsal atelectasis associated with the commonly used supine position might also contribute to this shunt. Reports indicate that obese patients may be more likely to develop dorsal atelectasis than non-obese patients. The investigators hypothesized that opening the body position angle at the waist from a typical head of bed at 30 degrees to one similar to a more upright reverse trendelenburg position, would alter the position of the diaphragm downward, allowing for improved aeration of lung bases. Thus, the investigators examined the upright body positioning in mechanically ventilated patients with ARDS primarily by evaluating for effects on oxyhemoglobin saturation (O2sat), Tidal Volume (TV) and Respiratory Rate (RR).
Key facts
- Study ID
- NCT02160561
- Run by
- Wake Forest University Health Sciences
- People needed
- 10
- Starts
- 2013-04-01
- Expected to finish
- 2015-06-01
- Last updated by the study team
- 2018-08-09
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Mechanically ventilated
- Chest radiograph must show parenchymal lung infiltrates.
- Acute Lung Injury
- Study shall occur 96 hours after consent has been obtained
You may not qualify if…
- Hemodynamic instability and/or use of a vasopressor within the last 6 hours prior to enrollment.
- Pregnant patients.
Where it is running
- Wake Forest Baptist Health, Medical Intensive Care Unit — Winston-Salem, North Carolina, United States
Full record on ClinicalTrials.gov
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