The Drug Induced Renal Injury Consortium

Completed

Conditions studied: Acute Kidney Injury, Adverse Drug Reaction, Acute Kidney Failure, Kidney Failure, Kidney Disease

In brief

Some medications are known to cause kidney damage because the person is allergic to the medication while others cause direct damage to the kidney because they are toxic at certain concentrations. Risk factors for developing kidney damage have been identified for some medications but not for all. Patients who are exposed to these important medications and develop problems with their kidneys may have some genetic risk. The purpose of this study is to determine the genetic risk factors for drug induced kidney injury. A better understanding of the role of genetics for the development of kidney injury from medications will allow us to better select medications, improve effectiveness of treatment and minimize harm.

Key facts

Study ID

NCT02159209

Run by

Ravindra Mehta

People needed

634

Starts

2013-02-01

Expected to finish

2015-12-01

Last updated by the study team

2016-04-21

Who can join

Age: 2 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients age 2 years and older
• Exposure to a candidate drug for at least 24 hours (see above)
• Patients who have developed DIRI as defined by the primary criteria
• Written informed consent or assent and consent obtained
• If patient lacks capacity to consent then surrogate consent will be obtained

You may not qualify if…

• Patients with a history of or have a kidney transplant
• Patients with a history of or have a bone marrow transplant
• Patients with Chronic Kidney Disease stage 5 (eGFR < 15 mL/min/1.73m2)
• Patients on 3 or more causal drugs
• Patients with no history or time course on drug exposure
• Patient who, in the opinion of the Investigator, is not suitable to participate in the study.
• Unable to obtain written informed consent or assent
• Unable to obtain surrogate consent for patients who lack capacity

Where it is running

• University of Alabama, Birmingham — Birmingham, Alabama, United States
• University of California, San Diego — San Diego, California, United States
• Rady Children's Hospital — San Diego, California, United States
• University of Colorado — Aurora, Colorado, United States
• University of Michigan — Ann Arbor, Michigan, United States
• St. Peter's Hospital — Albany, New York, United States
• Jacobi Medical Center — New York, New York, United States
• Cincinnati Children's Hospital — Cincinnati, Ohio, United States
• Universidad del Valle, Cochabamba — Cochabamba, Bolivia
• Hopital Sacre Coeur & Universite de Montreal — Montreal, Quebec, Canada
• Universidad de Los Andes — Santiago, Chile
• CARE Hospitals — Banjara Hills, Hyderabad, India
• Postgraduate Institute of Research, Chandigarh — Chandigarh, India
• Newcastle University — Newcastle upon Tyne, Tyne and Wear, United Kingdom
• St James's University Hospital — Leeds, West Yorkshire, United Kingdom
• Royal Free Hospital — London, United Kingdom
• Guy's & St Thomas's Hospital — London, United Kingdom
• University of Nottingham — Nottingham, United Kingdom

Full record on ClinicalTrials.gov

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