The Dose-Response Relationship of Rocuronium in Patients Taking Pyridostigmine

Withdrawn before enrolling

Conditions studied: Muscle Relaxants

In brief

Pyridostigmine is a medication that is used in certain heart rate and blood pressure conditions. This medication, as a side effect, is known to also cause changes in the junction between a nerve and muscle. The changes caused at the nerve muscle junction by pyridostigmine could alter the effect of muscle relaxants (a medication used during surgery and anesthesia). The investigators are conducting this study to see whether patients taking pyridostigmine are more or less sensitive to rocuronium (a muscle relaxing medication used during surgery).

Key facts

Study ID

NCT02157545

Run by

Shashi Bhatt, MD

People needed

0

Starts

2014-03-01

Expected to finish

2016-05-01

Last updated by the study team

2016-07-19

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients who take pyridostigmine for any reason or those who are matched by age, sex and weight to subjects taking pyridostigmine
• Patients who will be administered rocuronium during elective procedures as standard clinical care.

You may not qualify if…

• Allergy to rocuronium
• Known neuromuscular disorder, patients suffering from myasthenia gravis
• Subjects taking medications known to impact neuromuscular transmission (ex. gentamicin).

Where it is running

• University of Toledo, Health Science Campus — Toledo, Ohio, United States

Full record on ClinicalTrials.gov

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