Racial and Aging Effects of Acute Antioxidant Supplementation
Completed · Not applicable · Has a placebo group
Conditions studied: Healthy
In brief
This research is,being done to better understand how antioxidants (vitamins C, E and Alpha Lipoic Acid) af,f,ect the heart,and arteries. For this study, we will obtain blood samples to measure oxidative stress markers (substances in the blood that are linked to oxidative stress), cholesterol, insulin and blood glucose (sugar), as well as measure how well the heart and arteries are working following supplementation with the antioxidants. Our central hypothesis is that acute antioxidant supplementation will improve arterial function at rest and during exercise in African Americans without an impact of age, whereas aging will modify these effects in Caucasians.
Key facts
- Study ID
- NCT02157207
- Run by
- University of Illinois at Chicago
- People needed
- 93
- Starts
- 2014-04-01
- Expected to finish
- 2015-06-01
- Last updated by the study team
- 2015-06-16
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- 18-35 or 55-75 years of age
- General Good health
- Without diagnosed atherosclerotic disease
- Without metabolic or inflammatory disease
- Do not use antioxidant vitamin supplementation
- Do not use anti-inflammatory medication within last 2 weeks
- Do not use steroidal substances within past 2 weeks
- Participants on medications (not listed in the Exclusion Criteria) will take medication as normal on all days of study visits.
You may not qualify if…
- Current smoker
- Severe obesity (BMI>40 kg/m2)
- Blood pressure greater than 140/90 mmHg
- Diabetes (fasting glucose >110 mg/dl)
- Hyperlipidemia (total cholesterol >240 mg/dl)
- Inflammatory disease (rheumatoid arthritis, systemic lupus erythematosus, etc)
- Diagnosed atherosclerotic heart disease
- Diagnosed cardiac arrhythmia
- Bacterial, viral or upper respiratory infection within past 1 month
- Bleeding disorder
- Anticoagulant medication
- Pregnant women
Where it is running
- University of Illinois - Chicago — Chicago, Illinois, United States
Full record on ClinicalTrials.gov
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