D-serine and Cognitive Remediation in Schizophrenia

Completed · Phase 2

Conditions studied: Schizophrenia

In brief

The investigators will test the effects of 3 days of D-serine (DSR) on auditory plasticity in a sensory based remediation (SBR) paradigm

Key facts

Study ID

NCT02156908

Run by

Nathan Kline Institute for Psychiatric Research

People needed

8

Starts

2014-08-01

Expected to finish

2015-12-01

Last updated by the study team

2020-10-08

Who can join

Age: 18 and older, up to 64. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18 to 64 years old,
• IQ≥85 and
• estimated Glomerular Filtration Rate (GFR) ≥60. All oral and depot antipsychotics (with the exception of clozapine) are allowable. Patients must be on their antipsychotic medication for 1 month and stable on dose of antipsychotic and adjunctive medications for 2 weeks prior to study entry.

You may not qualify if…

• history of neurological visual or hearing impairment,
• active suicidal ideation on the Columbia Suicide Severity Rating Scale (C-SSRS),
• current alcohol or drug abuse (<1 month) or substance dependence (<4 months). All women of child-bearing potential must have a negative urine pregnancy test at the baseline visit. We require an IQ of ≥85 to ensure that subjects will have a capacity to learn. In our cross-sectional studies, we have observed an IQ≥85 in over 90% of candidates, suggesting that this is not an overly restrictive criterion.

Where it is running

• Nathan Kline Institute — Orangeburg, New York, United States

Full record on ClinicalTrials.gov

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