Why do Oral Contraceptives Prevent Ovarian Cancer?
Completed · Early Phase 1
Conditions studied: Ovarian Cancer Risk, Risk-reducing Surgery, Fallopian Tube Fimbriae, Ovarian Cortical Inclusion Cysts
In brief
Use of oral contraceptives (OCs) reduces a woman's risk of ovarian cancer very significantly and the protective effect continues for at least 25 years after use of OCs is stopped; the mechanisms of how this occurs are not understood. We are proposing here to directly study the effect of OCs on the fallopian tube and inclusion cysts within the ovary - sites from which most ovarian cancers are thought to arise - in order to better understand the mechanistic basis for OC protection against ovarian cancer. We think the protection results from reduced cell proliferation. It will lay the foundation for further studies to ensure that the protection against ovarian cancer afforded by 'traditional' OCs is not lost with alterations in OC formulation, and, if possible, to guide development of OC formations to improve further on the protection afforded by OCs.
Key facts
- Study ID
- NCT02155777
- Run by
- University of Michigan
- People needed
- 52
- Starts
- 2014-06-01
- Expected to finish
- 2018-06-01
- Last updated by the study team
- 2020-06-25
Who can join
Age: 30 and older, up to 45. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Premenopausal
- 30 and 45 years of age
- Scheduled to undergo a laproscopically conducted RR-BSO, risk reducing salpingectomy, salpingectomy for sterilization, or salpingectomy with hysterectomy for non-cancer related conditions
- Have at least one ovary
You may not qualify if…
- Past hysterectomy
- Past diagnosis of ovarian cancer
- Use of Tamoxifen, Raloxifene or hormone replacement therapy in the past 3 months
- Use of Chemotherapy in the last 6 months
Where it is running
- USC Keck School of Medicine — Los Angeles, California, United States
- University of Michigan — Ann Arbor, Michigan, United States
- UBC BC Cancer Agency — Vancouver, British Columbia, Canada
Full record on ClinicalTrials.gov
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