Exercise and Markers of Medial Temporal Health in Youth At-risk for Psychosis

Completed · Not applicable

Conditions studied: Attenuated Psychosis Syndrome

In brief

The goal of this proposal is to test the feasibility and effectiveness of cardiovascular exercise in promoting brain health and improving related symptoms (e.g., hearing sounds that are not there, feeling emotionally detached from self and others), cognitive difficulties (troubles with memory and learning), and every day social-occupational functioning in youth at imminent risk for developing a psychotic disorder such as schizophrenia. Understanding how exercise may protect or improve the health of a brain area that is implicated as a major contributing factor to the onset of psychosis may lead to a path-breaking new intervention that does not suffer from many of the side effects, costs, and other barriers that characterize treatments that are currently available for this group. Because a significant portion of high-risk youth go on to develop a psychotic disorder in a short period, intervening at this stage may help to improve the clinical course and ultimately prevent the onset of a devastating and prevalent mental illness.

Key facts

Study ID

NCT02155699

Run by

University of Colorado, Boulder

People needed

50

Starts

2014-07-01

Expected to finish

2022-07-01

Last updated by the study team

2024-04-02

Who can join

Age: 16 and older, up to 24. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• age 16-24
• no history of brain injury or neurological disease
• no contraindications to exercise training (as assessed by a Clinical Translational Research Center CTRC physician)
• no history or current treatment with antipsychotics
• no contraindications for being in an magnetic resonance imaging scanner.
• meet criteria for a prodromal syndrome based upon the Structure Interview for Prodromal Syndromes (SIPS) interview.

You may not qualify if…

• people who are extremely claustrophobic
• have a history of significant head injury
• other physical disorder that could affect brain functioning
• mental retardation
• history of substance use disorder within 6 months of screening interview
• have a psychotic disorder (at study entry) and/or have exhibited serious self-harm behaviors
• pregnant females
• people who have contraindications to magnetic resonance (MR) scanning including intracranial, intraorbital or intraspinal metal, pacemakers, cochlear implants or other non-MR-compatible devices
• inability of the subject or their parent/guardian to understand the informed consent document
• meeting criteria for an Axis I psychotic disorder

Where it is running

• ADAPT Program — Boulder, Colorado, United States

Full record on ClinicalTrials.gov

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