Improving the Concentration of MR Contrast in the Arteries

Completed · Not applicable

Conditions studied: Magnetic Resonance Angiography, Contrast Media

In brief

In Contrast-Enhanced Magnetic Resonance Angiography (CE-MRA) a contrast agent is injected into an arm vein using a programmable medical device called a power injector. Once the contrast has circulated to the blood vessel of interest they can be imaged with MRI and distinctly separated from surrounding non-vascular tissue. This project is designed to find the best way to administer the contrast agent during CE-MRA to produce the best images. The clinical availability of programmable power injectors facilitates the use of variable contrast rate and volume injection protocols that are based on patient specific parameters. CE-MRA is a valuable imaging tool for diagnosing abnormalities of the major blood vessels in the chest and abdomen. It is often used in conjunction with cardiac magnetic resonance (CMR) examinations to evaluate the blood vessels of the heart and lung. CE-MRA is attractive because 1) it does not involve radiation, and 2) the contrast agents used are not toxic to the kidneys and can be used in patients who are at greater risk for kidney dysfunction following iodinated contrast agents. We plan to administer a small (1cc) test amount of contrast, taking pictures as the contrast passes through the blood vessels, and analyze the results. Using this information, we will administer an individually patient-tailored injection given in multiple phases (i.e., a "multi-phasic" injection) to maintain constant contrast concentration (and therefore constant signal intensity) throughout the scan. We believe this will reduce image blurring, and improve the sharpness and likely the diagnostic quality of CE-MRA.

Key facts

Study ID

NCT02155218

Run by

University of Washington

People needed

26

Starts

2014-06-01

Expected to finish

2015-11-01

Last updated by the study team

2017-10-26

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18 years of age or older;
• Scheduled at University of Washington Radiology to undergo contrast-enhanced cardiac MR.

You may not qualify if…

• Unable to understand the nature of the study or to consent;
• Unwilling to participate;
• Prisoner;
• Pregnant;
• Contraindications for MRI:
• Metallic or other surgical implants
• History of metal work; metal pieces in your eyes or other body parts
• pacemaker
• defibrillator
• some aneurysm clips
• some artificial heart valves
• some implanted venous access device
• some cochlear/inner ear implants
• spinal stimulator
• some intrauterine devices (IUD)
• some tattoos or permanent make-up
• transdermal patch
• severe anxiety in confined spaces (claustrophobia)
• Contraindications for contrast:
• an allergic reaction to gadolinium contrast in the past that required treatment
• severe kidney or liver disease

Where it is running

• University of Washington — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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