A Thorough QT Study of Telotristat Etiprate
Completed · Phase 1 · Has a placebo group
Conditions studied: QT Interval
In brief
The purpose of this study is to demonstrate that telotristat etiprate does not differ from placebo in the mean change from Baseline QT interval corrected for heart rate.
Key facts
- Study ID
- NCT02155205
- Run by
- Lexicon Pharmaceuticals
- People needed
- 48
- Starts
- 2014-05-01
- Last updated by the study team
- 2014-09-08
Who can join
Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Healthy adult males or females ≥18 to ≤55 years of age (inclusive) at the time of Screening
- Body mass index ≥18 to ≤32 kg/m2 at Screening
- Vital signs (after at least 5 minutes resting in a supine position) at Screening which are within the following ranges: Systolic blood pressure 90 to 140 mm Hg, Diastolic blood pressure 50 to 90 mm Hg, heart rate 45 to 100 beats per minute (bpm)
- Clinical laboratory evaluations (including clinical chemistry panel [fasted at least 10 hours], complete blood count, and urinalysis [UA]) within the reference range for the test laboratory, unless deemed not clinically significant by the Investigator
- Able to tolerate prolonged periods of quiet, motionless, supervised rest
- Willing to adhere to the prohibitions and restrictions specified in this protocol
- Able to comprehend and willing to sign an Informed Consent Form
You may not qualify if…
- Presence of clinically significant physical, laboratory, or ECG findings at Screening that, in the opinion of the Investigator or Sponsor, may interfere with any aspect of study conduct or interpretation of results
- >30 premature ventricular beats per hour on the Holter ECG monitoring at Day -1 of Period 1 (monitored at the clinic via telemetry)
- History of additional risk factors for torsade de pointes or the diagnosis or suggestion of a family history of short QT syndrome or long QT syndrome
- History of renal disease or significantly abnormal kidney function tests
- History of hepatic disease or significantly abnormal liver function tests
- History of any clinically significant psychiatric, renal, hepatic, pancreatic, cardiovascular, neurological, or gastrointestinal abnormality
- Concurrent conditions that could interfere with safety and tolerability measurements
- Positive hepatitis panel (including hepatitis B surface antigen and hepatitis C virus antibody) or positive human immunodeficiency virus antibody screens
- Use of tobacco, use of medications, or history of any disease or condition that might interfere with the conduct of the study in the opinion of the investigator
Where it is running
- Lexicon Investigational Site — Evansville, Indiana, United States
Full record on ClinicalTrials.gov
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