Study of Airflow in the Lungs Using Helium MRI

Completed · Not applicable

Conditions studied: COPD, Healthy, Constrictive Bronchitis

In brief

Computer simulations are being developed to predict air flow abnormalities in the airways of patients with lung disease. The purpose of this study is to obtain actual gas flow measurements in the lungs of healthy patients and patients with lung disease and use these measurements to validate the computer models.

Key facts

Study ID

NCT02154568

Run by

University of Virginia

People needed

24

Starts

2013-11-07

Expected to finish

2026-02-26

Last updated by the study team

2026-03-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy subjects:
• Normal PFT values: FEV1 > 90% predicted; and Forced vital capacity (FVC) > 90% predicted
• Normal chest x-ray (CXR)
• Medical history: No active pulmonary symptoms (cough, shortness of breath, sputum); Negative history of pulmonary disease; Negative smoking history (never smoked)
• Pulmonary Disease Subjects:
• PFT values: FEV1/FVC < 70% (indicative of obstruction); and 30% < FEV1 < 50% predicted
• CXR normal except hyperinflation
• Symptoms - chronic shortness of breath
• All test subjects, healthy and with COPD should have similar physical anthropometric characteristics:
• Similar age with age difference less than 3 years
• Similar height (within 3-4 inches)

You may not qualify if…

• Any condition for which a MRI procedure is contraindicated.
• Presence of any non-MRI compatible metallic material in the body, such as pacemakers, metallic clips, etc.
• Likelihood of claustrophobia
• Chest circumference greater than that of the helium MR coil.
• Pregnancy, by report of subject. Clinically in the Department of radiology at UVA, self report is used when screening patients for MR scans as well as CT scans and fluoroscopy studies. If the subject reports there is any chance of their being pregnant a urine pregnancy test will be performed prior to any imaging.

Where it is running

• Snyder Translation Fontaine Research Center 480 Ray C. Hunt Drive — Charlottesville, Virginia, United States
• University of Virginia Health System — Charlottesville, Virginia, United States

Full record on ClinicalTrials.gov

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