Effects of Brief Training on Craving Regulation

Completed · Not applicable

Conditions studied: Nicotine Addiction

In brief

The investigators propose that brief training in regulation of craving may increase the efficacy of smoking cessation, but that training in cognitive vs. mindfulness-based strategies may operate via different psychological and neural mechanisms.

Key facts

Study ID: NCT02153749
Run by: Yale University
People needed: 92
Starts: 2015-09-01
Expected to finish: 2019-07-01
Last updated by the study team: 2020-04-13

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Between the ages of 18 and 60
Smoking 10 or more cigarettes per day,
Score >4 on the Fagerstrom Test For Nicotine Dependence (FTND)
Treatment seeking (motivated to quit or reduce smoking; >6 on a 10 point likert scale)
Fluent English speaker
Can commit to the full length of the protocol (\~8 weeks) and
Are willing to be randomized to treatment condition.

You may not qualify if…

Current or past comorbid Axis I disorders (assessed via the Mini Psychiatric Interview Diagnosis; MINI)
Current use of any psychoactive medications that have not been at a stable dose for the past 6 months, are used as mood stabilizers, or are used as smoking cessation treatments (e.g. varenicline).
Serious or unstable medical condition within past 6 months
Use of an investigational drug currently or within past 30 days
Use of psychoactive medications or those that affect blood flow
Other conditions contra-indicated for MRI (e.g., claustrophobia, presence of ferromagnetic metal in the body, prior head trauma with loss of consciousness, color blindness, hypertension, pregnancy).
For females only: pregnancy.

Where it is running

Clinical & Affective Neuroscience Lab — New Haven, Connecticut, United States

Full record on ClinicalTrials.gov

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