Study of the Effects of BMS-919373 on the Electrical Activity of the Heart Using Pacemakers
Stopped early · Phase 1 · Has a placebo group
Conditions studied: Atrial Fibrillation
In brief
To determine the effect of our compound (BMS-919373) on electrical activity of the heart using pacemakers.
Key facts
- Study ID
- NCT02153437
- Run by
- Bristol-Myers Squibb
- People needed
- 7
- Starts
- 2014-10-30
- Expected to finish
- 2016-10-20
- Last updated by the study team
- 2023-12-19
Who can join
Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 18 years to 85 years.
- Eligible patients will have a dual-chamber permanent pacemaker.
- Women who are not of childbearing potential.
You may not qualify if…
- Patients with a history of Atrial Fibrillation (AF) that is either:.
- i) Permanent (i.e. patients are only in AF and never in sinus rhythm) or.
- ii) Persistent (i.e. patients who's episodes of AF are longer than 7 days and require medical intervention, such as electrical or medical cardioversion, to return to sinus rhythm), are excluded.
- History of Transient Ischemic Attack (TIA) or stroke in the last 12 months.
- History of clinically significant ventricular arrhythmia (not including isolated monomorphic Premature Ventricular Contractions (PVCs)). Such arrhythmias are marked by loss of consciousness, emergent cardioversion or defibrillation or unstable vital signs requiring medical intervention.
- Complete heart block.
- Planned surgery, endovascular intervention or cardioversion within the study period.
- History of atrial fibrillation.
- Other protocol-defined Inclusion/Exclusion criteria apply.
Where it is running
- Local Institution — Austin, Texas, United States
- The University Of Calgary — Calgary, Alberta, Canada
- University Of Ottawa Heart Institute — Ottawa, Ontario, Canada
- Local Institution - 0001 — Toronto, Ontario, Canada
- Local Institution - 0002 — Montreal, Quebec, Canada
- Local Institution — Montreal, Quebec, Canada
Full record on ClinicalTrials.gov
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