Cerebral Oxygenation and Autoregulation in Preterm Infants

Completed

Conditions studied: Intraventricular Hemorrhage of Prematurity, Complications of Prematurity

In brief

Premature infants are at high risk for variations in blood pressure and oxygenation during the first few days of life. The immaturity of the premature brain may further predispose these infants to death or the development of neurologic problems. The relationship between unstable blood pressure and oxygen levels and brain injury has not been well elucidated. This study investigates the utility of near-infrared spectroscopy (NIRS), a non-invasive oxygen-measuring device, to identify preterm infants at highest risk for brain injury or death.

Key facts

Study ID

NCT02147769

Run by

Stanford University

People needed

111

Starts

2014-05-01

Expected to finish

2018-03-01

Last updated by the study team

2020-04-07

Who can join

Age: any, up to 0. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• inborn
• birth weight <= 1250 grams
• indwelling arterial catheter in place
• age <24 hours old

You may not qualify if…

• lethal chromosomal abnormality
• major congenital anomaly
• skin integrity insufficient to allow placement of NIRS sensors
• decision to not provide full intensive care

Where it is running

• University of Alabama — Birmingham, Alabama, United States
• Stanford University — Palo Alto, California, United States
• Santa Clara Valley Medical Center — San Jose, California, United States
• Yale-New Haven Children's Hospital — New Haven, Connecticut, United States
• St. John's Children's Hospital — Springfield, Illinois, United States
• Nationwide Children's Hospital — Columbus, Ohio, United States
• UT Southwestern Medical Center — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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