Effects of Hookah Smoking on Blood Flow to the Heart, Muscle and Skin
Completed · Not applicable
Conditions studied: Hookah Smoking
In brief
This is a pilot study on acute effects of Hookah smoking on the sympathetic neural control of the human cardiovascular system. Hookah smoking is known to transiently increase blood pressure and heart rate while decreasing heart rate variability suggesting - but not proving - sympathetic mediation. Here the investigators will directly measure the acute effects of Hookah smoking on sympathetic nerve activity with microneurography (intraneural microelectrodes) and quantify associated regional changes in vasomotor tone.
Key facts
- Study ID
- NCT02147665
- Run by
- Cedars-Sinai Medical Center
- People needed
- 42
- Starts
- 2013-03-01
- Expected to finish
- 2016-03-01
- Last updated by the study team
- 2020-01-13
Who can join
Age: 18 and older, up to 39. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- 18 to 39 years of age
- Habitual Hookah smoker defined as having smoked Hookah >=12 times in the past 12 months
- Have not smoked cigarettes within the past 12 months
You may not qualify if…
- Exhaled carbon monoxide level greater than 10 ppm* as evidence of current or recent cigarette (excluded if smoked cigarette within 12 months) or Hookah smoking (excluded if smoked Hookah within past 72 hours)
- History of cardiopulmonary disease
- Use of any prescription medication with exception of oral contraceptive pills
- History of psychiatric illness
- History of neurologic disease
- BMI ≥ 35
- Evidence of any of the above by physical examination, ECG or echocardiogram
- Smoked cigarette in the past 12 months
- History of illicit drug use
- Pregnant
- Any other condition(s) deemed by the physician investigators that put subjects at risk for participating in the study
Where it is running
- Cedars-Sinai Medical Center — Los Angeles, California, United States
Full record on ClinicalTrials.gov
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