Brain Biomarkers w/Mind-Body Tx in Veterans With Post Traumatic Headache (PTH)

Stopped early · Not applicable

Conditions studied: Post Traumatic Headache

In brief

This project aims to develop and test structural and functional brain imaging biomarkers for improvement in chronic pain from a mind/body intervention perspective in a critical veteran population, namely veterans with post traumatic headache (PTH) associated with mild traumatic brain injury (TBI). The project also aims to examine feasibility in a sample of veterans with PTH of performing resting state and structural neuroimaging protocols, and of obtaining active participation and completion of MBSR training. Lastly, exploratory analysis of brain imaging data will be performed to determine if hypothesized candidate biomarkers are associated with positive outcomes from MBSR and determine estimated effect sizes for future studies in PTH population.

Key facts

Study ID

NCT02145117

Run by

University of California, Los Angeles

People needed

21

Starts

2013-09-01

Expected to finish

2016-04-01

Last updated by the study team

2026-08-03

Who can join

Age: 18 and older, up to 60. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Males and female veterans at least 18 years of age
• Mild post traumatic headaches, diagnosed by a physician
• No prior training in MBSR or other mindfulness or meditation training will be allowed
• Able to read and speak English
• No participation in a clinical trial within the last 28 days

You may not qualify if…

• Current severe psychiatric diagnoses (e.g., schizophrenia, bipolar disorder, claustrophobia, history of panic attacks)
• Significant co-morbid condition(s) such as insulin-dependent diabetes, cancer, obesity (BMI>35), severe lung disease, neurological conditions (e.g., seizures), uncontrolled hypertension, or significant heart disease
• History of persistent headaches prior to TBI
• Unsafe for MRI (e.g., metal objects/shrapnel, metallic implants, brain or skull abnormalities, and claustrophobia)
• Use of centrally acting medications that will interfere with the neuroimaging testing (e.g. narcotic medications)
• Daily use of illicit drugs or marijuana
• Daily alcohol consumption of greater than 2 units

Where it is running

• VA West Los Angeles Medical Center — Los Angeles, California, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.