Effect of Ankle Splinting on Vascular Function in Aging
Completed · Not applicable
Conditions studied: Aging
In brief
Endothelial function of the skeletal muscle vasculature declines with advancing age. Although aerobic exercise training is commonly prescribed to combat loss of endothelial function in the elderly, the rate of compliance to training programs is low. Contrary to aerobic exercise training, stretching exercise is widely performed in elderly patients to increase muscle flexibility and to prevent muscle atrophy induced by immobilization. However, it remains unknown as to whether regular stretching of the calf muscles using ankle dorsiflexion splinting improves muscle blood flow. The purpose of the proposed work is to test the hypothesis that performance of ankle dorsiflexion splinting improves endothelial function and lower leg muscle blood flow in older adults. Ankle dorsiflexion splinting will be performed on the randomized leg for 30 minutes, 5 times per week for 4 weeks. Leg vascular measures will be performed on the splinted and non-splinted legs prior to and at the end of the 4-week intervention.
Key facts
- Study ID
- NCT02144896
- Run by
- University of Florida
- People needed
- 17
- Starts
- 2014-05-01
- Expected to finish
- 2015-04-10
- Last updated by the study team
- 2018-04-05
Who can join
Age: 60 and older, up to 79. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Men and women aged 60 to 79 years.
- Women will all be postmenopausal and must not take hormone replacement therapy.
- Sedentary, defined as no regular exercise training.
You may not qualify if…
- No evidence of heart disease evidenced by abnormal resting ECG, angina or ECG evidence of acute myocardial ischemia during the exercise test, no history of any relevant acute cardiac event (myocardial infarction, episode of heart failure)
- No history of deep vein thrombosis.
- No history of Type I or II diabetes mellitus.
- No history for renal or liver disease.
- No history of seizures, or other relevant on-going or recurrent illness.
Where it is running
- University of Florida — Gainesville, Florida, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.