Electrical Activity of Diaphragm as a Means to Predict Extubation Success in Preterm Infants
Completed
Conditions studied: Respiratory Distress Syndrome
In brief
Mechanical ventilation used to support the sick newborn infant is associated with many complications including the development of chronic lung disease. Limiting prolonged invasive ventilation remains an important strategy to decrease lung injury and prevent chronic lung disease. Currently, there is no objective measure available to predict readiness for removal of the endotracheal tube ("extubation") and discontinuing mechanical ventilation in this fragile population. The investigators propose to predict extubation success by evaluating the electrical activity of the diaphragm (Edi), which provides important information about the "drive" to breathing coming from the brain and the function of the diaphragm, two essential factors determining extubation readiness and success.
Key facts
- Study ID
- NCT02144363
- Run by
- Dartmouth-Hitchcock Medical Center
- People needed
- 21
- Starts
- 2014-08-01
- Expected to finish
- 2015-10-01
- Last updated by the study team
- 2016-03-11
Who can join
Age: any, up to 0. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Preterm infants less than 35 week gestation, requiring intubation and mechanical ventilation for respiratory distress in the first 24 hours of life
You may not qualify if…
- Infants with a non-intact esophagus (e.g tracheal-esophageal fistula or atresia), a non-functional diaphragm (e.g. phrenic nerve palsy), severe intracranial hemorrhage or structural CNS abnormality, severe birth asphyxia and critically sick infant needing paralysis or deep sedation.
Where it is running
- Dartmouth Hitchcock Medcial Center — Lebanon, New Hampshire, United States
Full record on ClinicalTrials.gov
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