Whole Body Vibration Combined With L-citrulline Supplementation on Cardiovascular Function and Body Composition
Completed · Not applicable · Has a placebo group
Conditions studied: Obesity, Pre-hypertension, Hypertension
In brief
Arterial dysfunction contributes to the development of cardiovascular disease (CVD), which is currently afflicting millions of individuals. The use of the amino acid L-citrulline has been suggested as a potential aid for the treatment of CVD by increasing endothelial production of Nitric Oxide (NO). Whole body vibration (WBV) is new and effective form of exercise that is feasible for clinical populations and has been proven to decrease blood pressure (BP) and arterial stiffness and increase muscle mass and strength. Therefore, the purpose of this study was to investigate if the combination of WBV training (WBVT) plus L-citrulline supplementation would induce positive additive effects and would be an effective means to ameliorate arterial stiffness, endothelial function, BP and muscle strength/mass in postmenopausal women.
Key facts
- Study ID
- NCT02143817
- Run by
- Florida State University
- People needed
- 60
- Starts
- 2013-03-01
- Expected to finish
- 2014-01-01
- Last updated by the study team
- 2015-03-10
Who can join
Age: 50 and older, up to 70. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- Female 50 to 70 years of age At least 1 year after menopause Body mass index of 27-39.9 Sedentary or low active (less than 2 hr per wk)
You may not qualify if…
- Younger than 50 or older than 70 years of age Body mass index lower than 27, or 40 or higher Physically active or competitively active Smoker Use of hormone replacement therapy of less than 1 yr Use of calcium channel blocker or beta blockers Use dietary supplementations (e.g.,L-arginine,L-citrulline,antioxidants) Uncontrolled diabetes Any restriction that would significantly interfere with compliance with the L-citrulline supplementation
Where it is running
- FSU College of Human Sciences — Tallahassee, Florida, United States
Full record on ClinicalTrials.gov
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