Sorafenib Tosylate With or Without Everolimus in Treating Patients With Advanced, Radioactive Iodine Refractory Hurthle Cell Thyroid Cancer
Running, not enrolling · Phase 2
Conditions studied: Refractory Hurthle Cell Thyroid Cancer
In brief
This randomized phase II trial studies the effects, good and bad, of using everolimus along with sorafenib tosylate versus sorafenib tosylate alone in treating patients with advanced radioactive iodine refractory thyroid cancer. Sorafenib tosylate and everolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. The addition of everolimus to sorafenib tosylate may cause more shrinkage of thyroid cancer and may prevent it from growing but it could also cause more side effects than sorafenib tosylate alone. It is not yet known whether this treatment with sorafenib tosylate and everolimus is better, the same, or worse than sorafenib tosylate alone.
Key facts
- Study ID
- NCT02143726
- Run by
- Alliance for Clinical Trials in Oncology
- People needed
- 35
- Starts
- 2014-10-09
- Expected to finish
- 2028-08-06
- Last updated by the study team
- 2026-02-11
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Mayo Clinic in Florida — Jacksonville, Florida, United States
- Northwestern University — Chicago, Illinois, United States
- Siouxland Regional Cancer Center — Sioux City, Iowa, United States
- University of Michigan Comprehensive Cancer Center — Ann Arbor, Michigan, United States
- Mayo Clinic — Rochester, Minnesota, United States
- Nebraska Methodist Hospital — Omaha, Nebraska, United States
- Memorial Sloan Kettering Basking Ridge — Basking Ridge, New Jersey, United States
- Memorial Sloan Kettering Monmouth — Middletown, New Jersey, United States
- Memorial Sloan Kettering Bergen — Montvale, New Jersey, United States
- Memorial Sloan Kettering Commack — Commack, New York, United States
- Memorial Sloan Kettering Westchester — Harrison, New York, United States
- Memorial Sloan Kettering Cancer Center — New York, New York, United States
- Memorial Sloan Kettering Sleepy Hollow — Sleepy Hollow, New York, United States
- Memorial Sloan Kettering Nassau — Uniondale, New York, United States
- Southeastern Medical Oncology Center-Clinton — Clinton, North Carolina, United States
- Southeastern Medical Oncology Center-Goldsboro — Goldsboro, North Carolina, United States
- Wayne Memorial Hospital — Goldsboro, North Carolina, United States
- Southeastern Medical Oncology Center-Jacksonville — Jacksonville, North Carolina, United States
- Ohio State University Comprehensive Cancer Center — Columbus, Ohio, United States
- Fox Chase Cancer Center — Philadelphia, Pennsylvania, United States
- Mercy Health System — Janesville, Wisconsin, United States
Full record on ClinicalTrials.gov
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