Rituxan and Abraxane for the Treatment of Patients With Inoperable Stage III and IV Malignant Melanoma

Status unconfirmed · Phase 2

Conditions studied: Malignant Melanoma of Skin Stage III, Metastatic Melanoma

In brief

The purpose of this research study is to test an experimental combination of drugs to determine if they can cause shrinkage or even complete disappearance of your melanoma. The two drugs being tested in combination are Rituxan and Abraxane

Key facts

Study ID

NCT02142335

Run by

California Cancer Assocaties for Research & Excellence

People needed

17

Starts

2014-03-01

Expected to finish

2016-03-01

Last updated by the study team

2014-05-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients must have inoperable stage III and IV melanoma.
• Patients will be included in the trial based on the following criteria:
• Patients previously treated with no more than 1 non-abraxane containing chemotherapy regimen or patients with the B-Raf mutation, who have received vemurafenib or the combination of Dabrafinib and trametinib (or similar compound on clinical trial) and progressed, who have documented surgically inoperable stage III or IV metastatic melanoma on pathologic examination of tissue. Previous treatment with immunotherapy is allowed. Patients who have been treated with either immunotherapy or chemotherapy must have be either 4 weeks from their last treatment or have fully recovered from all previous treatment.
• Measurable or evaluable non-CNS disease required as defined:
• Uni-dimensionally measurable lesion as determined by physical exam, X-ray, CT scan, MRI, or other radiographic procedure.
• Lesion that can be seen on a radiologic test but is not uni-dimensionally measurable
• Previously irradiated lesion allowed only with documentation of progression if no other metastatic site present.
• No active brain metastases Patients with previously treated brain metastases that have responded to therapy will be allowed on study assuming there is measurable disease outside of the CNS. Active therapy for the CNS disease must be completed a minimum of 3 weeks for chemotherapy and 6 weeks for radiation therapy (prior to enrollment on this study).
• Prior/ Concurrent therapy
• Biologic therapy No concurrent biological therapy with the exception of growth factors for anemia, neutropenia or thrombocytopenia.
• Chemotherapy No greater than 1 previous non-abraxane containing chemotherapy treatment allowed
• Radiotherapy At least 6 weeks since completion of radiotherapy
• Patient characteristics Age and ability to give informed consent Patients must be 18 years of age or older. Patients must have the ability to give informed consent.
• Performance status ECOG 0-2 Life expectancy of at least 3 months
• General Medical Concerns:
• Normal organ function, except if abnormal due to tumor involvement.
• Men and women of reproductive potential must agree to use an acceptable method of birth control during treatment and for twelve months after completion of treatment.
• Subject has provided written informed consent.
• Rituximab-Specific Concerns:
• ANC: > 1200/mm3
• Platelets: > 100,000/mm3
• Hemoglobin: > 9 gm/dL
• Adequate renal function as indicated by serum creatinine measurement < 1.5 x the upper limit of normal or GFR > 50 ml/min.
• Adequate liver function, as indicated by bilirubin < 3.0
• AST or ALT <2x Upper Limit of Normal unless related to primary disease.

You may not qualify if…

• Life expectancy less than 3 months
• Untreated brain metastasis
• Previous treatment with Abraxane containing regimen

Where it is running

• California Cancer Associates For Research,cCARE — Encinitas, California, United States (enrolling)

Full record on ClinicalTrials.gov

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