The Tailgate Study: A Pilot Study Measuring the Impact of Acute Alcohol Intake on Intrahepatic Lipid

Completed

Conditions studied: Obesity

In brief

College drinking associated with sporting events is characterized by excess alcohol, along with food intake, over the duration of hours has the potential to cause a build up of fat in the liver. Fatty liver can increase blood glucose concentrations leading to a prediabetes like state. The present study will determine how overweight men respond to the over-consumption of alcohol/food to identify which characteristics might protect some men from fatty liver, while others might be more susceptible to this condition. The goal of this work is to determine the direct impact of alcohol/food intake to cause acute fatty liver through the stimulation of de novo lipogenesis in 20 overweight, healthy men. Understanding individual susceptibility to alcohol-induced fatty liver will aid in the development of strategies designed to help people mitigate these risks. Hypothesis is that 5h excess consumption of alcohol and food will increase liver triglycerides by 4% or more, in comparison to fasting state.

Key facts

Study ID

NCT02141880

Run by

University of Missouri-Columbia

People needed

25

Starts

2014-06-01

Expected to finish

2020-01-01

Last updated by the study team

2020-11-02

Who can join

Age: 21 and older, up to 40. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Men
• Age 21-40
• BMI 25.1-35.0 kg/m2
• Waste girth < 55 inches
• Nonsmoking
• Moderate consumer of alcohol
• Fasting blood glucose < 125 mg/dL, alanine transaminase activity < 40 milliunits/L, plasma triglycerides < 200 mg/dL
• Sedentary
• Free of metabolic disorders

You may not qualify if…

• BMI < 25.1 or > 35.0 kg/m2
• Waste girth of greater 55 inches
• Use of any tabacco product
• Fasting plasma glucose ≥125 mg/dL, alanine transaminase activity ≥ 40 milliunits/L, plasma triglycerides ≥125 mg/dL
• Physically active
• Diabetes or other diseases that impact blood glucose or lipids
• Fatty liver disease

Where it is running

• University of Missouri — Columbia, Missouri, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.