n-Acetylcysteine and Cocaine

Completed · Early Phase 1 · Has a placebo group

Conditions studied: Cocaine Abuse, Cocaine Dependence

In brief

This study will determine the initial efficacy, safety and tolerability of n-acetylcysteine as a pharmacotherapy for cocaine dependence. A rigorous, inpatient human laboratory study will be conducted in which the subjective, physiological and reinforcing effects of cocaine are evaluated during maintenance on placebo and n-acetylcysteine.

Key facts

Study ID

NCT02141620

Run by

University of Kentucky

People needed

15

Starts

2014-05-01

Expected to finish

2016-04-01

Last updated by the study team

2017-01-04

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Current cocaine use
• Current cigarette smoker

You may not qualify if…

• Abnormal screening outcome (e.g., ECG, blood chemistry result) that study physicians deem clinically significant
• Current or past histories of substance abuse or dependence that are deemed by the study physicians to interfere with study completion
• History of serious physical disease, current physical disease, impaired cardiovascular functioning, chronic obstructive pulmonary disease, history of seizure or current or past histories of serious psychiatric disorder that in the opinion of the study physician would interfere with study participation will be excluded from participation
• Females not currently using effective birth control
• Contraindications to cocaine or n-acetylcysteine
• History of schizophrenia in first degree relative

Where it is running

• University of Kentucky Laboratory of Human Behavioral Pharmacology — Lexington, Kentucky, United States

Full record on ClinicalTrials.gov

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