Bone Health in Youth With Type 1 Diabetes
Status unconfirmed
Conditions studied: Type 1 Diabetes, Osteoporosis
In brief
This is an observational study of children and young adults ages 6-20 years with type 1 diabetes and age- and race-matched controls. The investigators will be examining blood and urine hormone levels as well as measures of bone density including DXA and high-resolution peripheral quantitiative computed tomography. The investigators will also be collecting data regarding physical activity via use of wearable accelerometers. The investigators hypothesize that youth with type 1 diabetes will have slower bone accrual and impaired bone microarchitectural integrity compared with non-diabetic controls, and that bones of individuals with type 1 diabetes will not respond as well to physical activity. The investigators hypothesize that poor bone accrual will be associated with sub-optimal glucose control as well as lower levels of insulin-like growth factor 1.
Key facts
- Study ID
- NCT02140424
- Run by
- Massachusetts General Hospital
- People needed
- 242
- Starts
- 2013-08-01
- Expected to finish
- 2024-07-01
- Last updated by the study team
- 2020-10-09
Who can join
Age: 6 and older, up to 20. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age 6-20 years
- Out of honeymoon period (cohort with diabetes)
You may not qualify if…
- BMI<5th percentile for age
- BMI>95th percentile for age
- Celiac disease
- Hyperthyroidism, uncontrolled hypothyroidism
- History of significant hepatic disease, renal disease, oncologic disease, cardiovascular disease, psychiatric disease
- Anemia (Hgb <11)
- Taking medications other than insulin known to affect bone health (including hormonal contraception, glucocorticoids, growth hormone)
Where it is running
- Massachusetts General Hospital — Boston, Massachusetts, United States (enrolling)
Full record on ClinicalTrials.gov
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