Validation of DaTscan for Detection of Parkinson Disease Related Disorders

Status unconfirmed

Conditions studied: Parkinson Disease, Movement Disorders

In brief

This investigator initiated trial is designed to measure the accuracy of diagnosis of Parkinson disease through the use of DaTscan. Currently, DaTscan is FDA approved to measure dopamine transporter densities in human tissue. This measurement can assist in distinguishing between Essential Tremor and Parkinsonian Syndromes (idiopathic Parkinson disease, Progressive Supranuclear Palsy, Multi Systems Atrophy, etc). This study will compare both clinical diagnosis of symptoms and the results of the scan to the pathological diagnosis received at time of death. Patients will be registered in the Parkinson Research Institute's brain donation program, receive a clinical diagnosis of Parkinson disease, have their brain scanned using DaTscan, and donate their tissue for research and autopsy purposes. The hypothesis of the study is that DaTscan will diagnosis Idiopathic Parkinson Disease as accurately as a clinician.

Key facts

Study ID: NCT02138682
Run by: Wisconsin Institute for Neurologic and Sleep Disorders S.C.
People needed: 20
Starts: 2014-07-01
Last updated by the study team: 2014-07-16

Who can join

Age: 75 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

aged 75 or older
sporadic late onset Parkinson disease or one of its variants
registered in tissue donation program

You may not qualify if…

aged less than 75 years old
mental status preventing neuroimaging or transportation to site
inability to remain "relatively steady" during the scanning procedure

Where it is running

Medical College of Wisconsin — Milwaukee, Wisconsin, United States
Wisconsin Institute for Neurologic and Sleep Disorders, SC — Milwaukee, Wisconsin, United States

Full record on ClinicalTrials.gov

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