Neuromodulation of Cognition in Older Adults

Completed · Not applicable · Has a placebo group

Conditions studied: Healthy

In brief

This study will investigate whether transcranial direct current stimulation enhances the effects of cognitive training in healthy older adults.

Key facts

Study ID

NCT02137122

Run by

University of Florida

People needed

31

Starts

2015-01-14

Expected to finish

2022-02-08

Last updated by the study team

2023-05-08

Who can join

Age: 65 and older, up to 90. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Men and women
• Age: 65 to 90 years
• English speaking
• Physically mobile
• working memory function between 0-75th percentile determined by screening results on the POSIT Baseline Cognitive Training computerized tasks.

You may not qualify if…

• Neurological disorders (e.g., dementia, stroke, seizures, traumatic brain injury).
• Evidence of dementia (NACC UDS scores of 1.5 standard deviations below the mean for age, sex and education adjusted norms in a single cognitive domain on the task).
• Past opportunistic brain infection.
• Major psychiatric illness (schizophrenia, intractable affective disorder, current substance dependence diagnosis or severe major depression and/or suicidality).
• Unstable (e.g., cancer other than basal cell skin) and chronic (e.g, severe diabetes) medical conditions.
• MRI contraindications (e.g., pregnancy, claustrophobia, metal implants that are contraindicated for MRI).
• Physical impairment precluding motor response or lying still for 1 hr and inability to walk two blocks without stopping.
• Certain prescription medications may possibly reduce effects otherwise induced by the tDCS stimulation protocol.
• Hearing or vision deficits that will not allow for standardized cognitive training.
• Left handedness

Where it is running

• University of Florida — Gainesville, Florida, United States
• McKnight Brain Institute — Gainesville, Florida, United States

Full record on ClinicalTrials.gov

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