Analgesic Response to Opioid Analgesics in Buprenorphine-Maintained Individuals
Status unconfirmed · Not applicable · Has a placebo group
Conditions studied: Analgesic Response
In brief
The aim of this study is to examine the effects of opioid analgesics on acute pain in participants maintained on buprenorphine+naloxone (Suboxone) for opioid use disorders. Seven medication conditions will be tested in a cold pressor test (CPT) paradigm.
Key facts
- Study ID
- NCT02136784
- Run by
- University of California, Los Angeles
- People needed
- 12
- Starts
- 2014-04-01
- Expected to finish
- 2014-12-01
- Last updated by the study team
- 2014-05-13
Who can join
Age: 20 and older, up to 50. Sex: male. Healthy volunteers: not accepted.
You may qualify if…
- Male, in good general health
- 20-50 years old
- Fluent in English
- Maintained on buprenorphine for at least 3 months
- Able to complete testing/assessments for 7 test days within 12 weeks
- Approved for participation by buprenorphine-prescribing physician
You may not qualify if…
- Known hypersensitivity to any of the test opioids
- Urine test positive for opioids (other than buprenorphine) or other illicit substances
- Current use of any additional opioid or analgesic medication (other than buprenorphine), medical marijuana, MAOI, tricyclic antidepressant, duloxetine, gabapentin, pregabalin, or other medication considered unsafe or having potential to influence pain perception as determined by study physician.
- Presence of acute pain condition or planned surgery during the study period
- Unstable vital signs as determined by the study physician.
- Current pattern of alcohol, benzodiazepine, or other sedative hypnotic use, as determined by the study medical clinician, which would preclude safe participation in the study;
- Pending legal action or other situation that might prevent remaining in the area for the duration of the study
- Current medical or psychiatric condition that could detract from study objectives, place the participant at risk, or interfere with treatment goals
Where it is running
- UCLA Integrated Substance Abuse Programs Outpatient Clinical Research Center — Los Angeles, California, United States (enrolling)
Full record on ClinicalTrials.gov
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