Echocardiography in Septic Shock
Status unconfirmed
Conditions studied: Septic Shock, Severe Sepsis
In brief
BACKGROUND: Echocardiography can provide evaluation of right or left ventricular dysfunction and volume status during resuscitation of patients with sepsis and septic shock and guide intravenous vasopressor and fluid therapy. While there are numerous echocardiographic studies regarding cardiac function and volume status in patients with established shock, there are none that describe these during the early resuscitation of septic shock. The study objective is to correlate echocardiographic findings with clinical parameters and net fluid balance measured during the early resuscitation of critically ill patients with sepsis and septic shock. Aim 1) correlate echocardiographic findings of cardiac function with physiologic markers in the early hours of resuscitation Aim 2) correlate cardiac function and fluid status with clinical outcomes Aim 3) evaluate the change in cardiac function over time in patients with sepsis and septic shock Aim 4) evaluate long term clinical outcomes for patients with sepsis and septic shock.
Key facts
- Study ID
- NCT02135796
- Run by
- Intermountain Health Care, Inc.
- People needed
- 700
- Starts
- 2008-10-01
- Expected to finish
- 2019-12-01
- Last updated by the study team
- 2019-06-13
Who can join
Age: 13 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- at least 13 years of age
- SEPSIS PATIENTS:
- Sepsis patients must have
- Suspected or confirmed infection
- AND
- Organ dysfunction as defined by a SOFA >= 2 above baseline (if no baseline data available, SOFA assumed to be 0)
- OR
- SEPTIC SHOCK PATIENTS:
- AFTER INFUSION OF 20ML/KG CRYSTALLOID OR EQUIVALENT, Septic shock patients must have
- Suspected or confirmed infection
- AND
- Lactate > 2 mmol/L
- AND
- Receiving vasopressors
- Enrollment of patients should occur within 8 hours of meeting criteria for severe sepsis or septic shock if it is required that a research only TTE be performed in the 0-6 hours after ICU admission. If a clinical TTE is performed in this timeframe, patients may be enrolled up to 24 hours after ICU admission.
You may not qualify if…
- None.
Where it is running
- Intermountain Medical Center — Murray, Utah, United States (enrolling)
Full record on ClinicalTrials.gov
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