Evaluating Fluid Strategies in Thoracic Surgery Patients Utilizing a Goal Directed Approach
Completed · Phase 4
Conditions studied: Hypotension, Kidney Injury
In brief
The purpose of this study is to conduct a prospective, randomized, controlled trial comparing a restrictive vs. conservative fluid strategy in thoracic surgery patients. Excessive perioperative fluid has been retrospectively implicated in the development postoperative acute lung injury (PALI) and pulmonary edema following lung resection. However, fluid restriction in these patients is not without risk and may compromise end organ perfusion (i.e. acute kidney injury). The hypothesis is that a conservative fluid approach in thoracic surgery patients will result in better end organ perfusion with fewer occasions of acute kidney injury (AKI) without causing an increase in postoperative acute lung injury or pulmonary edema.
Key facts
- Study ID
- NCT02135146
- Run by
- University of Colorado, Denver
- People needed
- 40
- Starts
- 2014-01-01
- Expected to finish
- 2016-09-01
- Last updated by the study team
- 2020-03-03
Who can join
Age: 18 and older, up to 89. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- between 18-89 years of age
- undergoing pulmonary lobectomy with open or video assisted thoracotomy
You may not qualify if…
- patient refusal
- pregnancy
- cardiac arrhythmia
- pacemaker dependency
- severe aortic insufficiency
- idiopathic hypertrophic subaortic stenosis
- prisoners
- decisionally challenged
- patients that refuse to receive intravenous fluid products made from human plasma (Albumin 5%)
- patients with skin infection or breakdown on their fingers
- severe peripheral vascular disease
- evidence of compromised finger perfusion will be excluded
Where it is running
- University of Colorado Hospital — Aurora, Colorado, United States
Full record on ClinicalTrials.gov
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