Mucosal Versus Fecal Microbiota in FMT

Completed

Conditions studied: Clostridium Difficile

In brief

Clostridium difficile infection is the most common cause of antibiotic-associated diarrhea. Treatment of this infection usually occurs using other antibiotics, but many individuals have persistent diarrhea and multiple relapses. Fecal Transplant (FMT), or Intestinal Microbiota Transplantation, (IMT) has been shown to be efficacious when administered after treatment for C. difficile. This study will involve taking biopsies from patients during their FMT/IMT via colonoscopy, and determine if there are differences in the mucosal flora as compared to the stool flora. The investigators hope to discover the critical parts of a healthy microbiota.

Key facts

Study ID

NCT02133651

Run by

Emory University

People needed

10

Starts

2014-04-01

Expected to finish

2015-08-01

Last updated by the study team

2015-12-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Inpatient or outpatient adults, age ≥18
• Have had at least 1 relapse of C. difficile
• Patients who have had previous FMT

You may not qualify if…

• Pregnant or breastfeeding
• Critically or acutely ill (Fever will be defined as a documented temperature >37.8°C)
• Ileus or toxic megacolon
• Unable to give consent

Where it is running

• Emory University Hospital — Atlanta, Georgia, United States

Full record on ClinicalTrials.gov

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