Buspirone, Stress, and Attentional Bias to Marijuana Cues
Completed · Phase 2 · Has a placebo group
Conditions studied: Cannabis Use Disorder
In brief
This project has two primary goals. The first goal is to further scientific understanding about marijuana abuse by examining two recognized factors in marijuana use and relapse: (1) stress/anxiety and (2) atypical reactivity to marijuana-related stimuli (e.g., attentional bias). The second goal is to attenuate the influence of stress/anxiety and attentional bias to marijuana stimuli via administration of buspirone. Buspirone is uniquely suited to this project because it has effects on neurotransmitter systems known to modulate both stress/anxiety and attentional bias.
Key facts
- Study ID
- NCT02132832
- Run by
- The University of Texas Health Science Center, Houston
- People needed
- 45
- Starts
- 2013-06-01
- Expected to finish
- 2016-03-01
- Last updated by the study team
- 2017-06-02
Who can join
Age: 18 and older, up to 45. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Marijuana substance use disorder based on a score of ≥ 13 on the Cannabis Use Disorders Identification Test - Revised (CUDIT-R)
- a score of ≥ 4 on the Cannabis Abuse Screening Test (CAST)
- meeting criteria for a marijuana substance use disorder based on the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders IV (DSM-IV)
You may not qualify if…
- Current DSM-IV Axis I disorder other than marijuana use disorder
- serious medical illness requiring ongoing medical treatment, which could affect the central nervous system, or any other medical contraindication (e.g., renal, cardiovascular, pulmonary, blood) as determined by medical screening
- a positive pregnancy test or breast feeding (females)
- concomitant use of prescription medications that could affect the central nervous system
- active suicidal ideation or Beck Depression Inventory II score greater than 19
- positive urine drug screen for drugs other than marijuana or positive breath alcohol screen
- Shipley-2 test of cognitive aptitude score outside 2 SD units of the published composite score average
- smoking > 10 nicotine cigarettes per day / Fagerstrom Score > 4
- taking meds known to have significant drug interactions with buspirone.
Where it is running
- University of Texas Health Science Center - Houston — Houston, Texas, United States
Full record on ClinicalTrials.gov
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