Autonomic Dysfunction in Non-Alcoholic Fatty Liver Disease
Completed
Conditions studied: Non-alcoholic Fatty Liver Disease, NAFLD, Fatty Liver, Nonalcoholic, Nonalcoholic Fatty Liver Disease
In brief
There is a significant association between autonomic dysfunction and symptoms experienced by NAFLD patients mediated by increased systemic inflammation and insulin resistance, resulting in deteriorating quality of life of affected patients; fatigue and other symptoms drive worsening autonomic dysfunction in these patients. We aim to describe the severity of autonomic dysfunction (AD) in non-alcoholic fatty liver disease (NAFLD) and the relationship of AD to symptoms experienced by NAFLD patients (such as fatigue, chronic pain, depression, sleep disturbance, and cognitive dysfunction), and to the quality of life of NAFLD patients. We also hope to examine the impact of systemic inflammation and insulin resistance as mediators of manifestations of AD and symptoms experienced by NAFLD patients.
Key facts
- Study ID
- NCT02132780
- Run by
- Virginia Commonwealth University
- People needed
- 25
- Starts
- 2014-05-01
- Expected to finish
- 2016-05-01
- Last updated by the study team
- 2017-06-12
Who can join
Age: 35 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Men and women within the age of 35-65
- understand and speak English
- NAFLD on liver histology by the biopsy within preceding 24 months
You may not qualify if…
- Patients with poorly controlled diabetes (HbA1c>8.5% or fasting blood glucose>150 mg/dl)
- renal dysfunction (Cr>1.5) last 3 months
- history of cardiac rhythm other than sinus rhythm
- on beta-blockers
- other liver diseases (HCV, HBV)
- decompensated cirrhosis (free of ascites hepatic encephalopathy, variceal bleeding)
- major depression
- cancer
- stroke
- any other major health conditions
Where it is running
- Virginia Commonwealth University Health System — Richmond, Virginia, United States
Full record on ClinicalTrials.gov
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