Rate Control Versus Rhythm Control For Postoperative Atrial Fibrillation

Completed · Phase 3

Conditions studied: Postoperative Atrial Fibrillation

In brief

The purpose of this study is to compare the therapeutic strategies of rate control versus rhythm control in cardiac surgery patients who develop in-hospital postoperative atrial fibrillation or atrial flutter (AF). In patients who develop AF during hospitalization after cardiac surgery, the hypothesis is that a strategy of rhythm control will reduce days in hospital within 60 days of the occurrence of AF compared to a strategy of rate control.

Key facts

Study ID

NCT02132767

Run by

Icahn School of Medicine at Mount Sinai

People needed

523

Starts

2014-05-01

Expected to finish

2015-09-01

Last updated by the study team

2019-03-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• LVAD insertion or heart transplantation
• Maze procedure
• TAVR
• History of or planned mechanical valve replacement
• Correction of complex congenital cardiac defect (excluding bicuspid aortic valve, atrial septal defect or PFO)
• History of AF or AFL
• History of AF or AFL ablation
• Contraindications to warfarin or amiodarone
• Need for long-term anticoagulation
• Concurrent participation in an interventional (drug or device) trial

Where it is running

• University of Southern California — Los Angeles, California, United States
• Emory University — Atlanta, Georgia, United States
• University of Maryland — Baltimore, Maryland, United States
• NIH Heart Center at Suburban Hospital — Bethesda, Maryland, United States
• University of Michigan Health Services — Ann Arbor, Michigan, United States
• Icahn School of Medicine at Mount Sinai — New York, New York, United States
• Columbia University Medical Center — New York, New York, United States
• Montefiore Einstein Heart Center — The Bronx, New York, United States
• Mission Hospital — Asheville, North Carolina, United States
• Duke University — Durham, North Carolina, United States
• Cleveland Clinic Foundation — Cleveland, Ohio, United States
• The Ohio State University Medical Center — Columbus, Ohio, United States
• University of Pennsylvania — Philadelphia, Pennsylvania, United States
• Baylor College of Medicine — Houston, Texas, United States
• Baylor Research Institute — Plano, Texas, United States
• University of Virginia Health Systems — Charlottesville, Virginia, United States
• University of Wisconsin — Madison, Wisconsin, United States
• University of Alberta Hospital — Edmonton, Alberta, Canada
• Toronto General Hospital — Toronto, Ontario, Canada
• Montreal Heart Institute — Montreal, Quebec, Canada
• Centre Hospitalier de l'Université de Montréal — Montreal, Quebec, Canada
• Hôpital du Sacré-Cœur de Montréal — Montreal, Quebec, Canada
• Institut Universitaire de Cardiologie de Quebec (Hopital Laval) — Québec, Quebec, Canada

Full record on ClinicalTrials.gov

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