Monocyte Phenotypic and Functional Differences
Completed
Conditions studied: Osteosarcoma
In brief
The purpose of this study is to identify phenotypic (cell surface receptor expression) and functional differences in monocyte populations in humans with osteosarcoma as compared to published historical data on normal human monocyte values. The biologic similarity between canine and human osteosarcoma makes it a disease model that holds promise for translational research possibilities. The phenotypic and functional differences the investigators expect to find in canine and human monocytes between normal and osteosarcoma subjects in this pilot work will allow us to launch a program of investigations to further their understanding as to what characteristics are associated with improved survival in canine and human osteosarcoma. Such data will represent the foundation upon which the investigators can plan future investigations designed to exploit the potential anti-tumor capabilities of monocytes and macrophages in canine and human osteosarcoma.
Key facts
- Study ID
- NCT02132182
- Run by
- Duke University
- People needed
- 15
- Starts
- 2014-10-01
- Expected to finish
- 2017-03-23
- Last updated by the study team
- 2018-06-29
Who can join
Age: 6 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients presenting for evaluation of osteosarcoma of the appendicular skeleton
- Patient is 6years or older at time of visit
- Patients do not need to be eligible for surgery
- Patients may have known infection related to osteosarcoma and its treatment (ex. surgical wound infection)
- Patients who would normally have a blood draw as part of their standard care
You may not qualify if…
- Patients younger than 10 years of age
- Patients who are unwilling/unable to undergo blood draw
- Patients with known infection unrelated to osteosarcoma or its treatment
- Patients with known systemic immune-mediated disease including but not limited to lymphoma, AIDS/HIV, Lupus, etc.
Where it is running
- Duke University Medical Center — Durham, North Carolina, United States
Full record on ClinicalTrials.gov
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