Defining Phenotypes of Movement Disorders :Parkinson's Plus Disorders (PD), Essential Tremor (ET), Cortical Basal Degeneration (CBD), Multiple Systems Atrophy (MSA), Magnetoencephalography.
Completed
Conditions studied: Essential Tremor, Multiple System Atrophy, Corticobasal Degeneration, Supranuclear Palsy, Progressive, Parkinson Disease
In brief
Investigators hypothesize that there are specific characteristic of each cognitive and motor condition that can be defined using brains scans.
Key facts
- Study ID
- NCT02132052
- Run by
- University of Colorado, Denver
- People needed
- 81
- Starts
- 2013-11-01
- Expected to finish
- 2014-05-01
- Last updated by the study team
- 2021-06-25
Who can join
Age: 40 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- All subjects will be age 40 or older,
- Be on stable medications for at least 30 days
- Montreal Cognitive Assessment (MOCA) of 26 or higher
- Scores within 1.5 standard deviations of age-matched norms for all neuropsychological tests
- Parkinson's Plus Disorders (PD) will be defined using United Kingdom (UK) Brain Bank Criteria.
- PD dementia (PDD) will be defined using the Movement Disorder Task Force 2007 criteria and supported by scores less than 1.5 standard deviations of age-matched norms in at least two domains.
- Probable Alzheimer's Disease (AD) will be defined using the National Institute on Aging-Alzheimer Association 2011 guidelines.
- Parkinson's Plus Disorders (PD) with mild cognitive impairment (MCI) will be defined by history, MOCA of 21 or higher, at least one score less than 1.5 standard deviations of age-matched norms, and cannot meet diagnostic criteria for PDD.
- Essential tremor and Parkinson plus syndromes (multiple systems atrophy, corticobasal degeneration, progressive supranuclear palsy) will be defined using previously published research criteria.19-22
You may not qualify if…
- Features suggestive of other causes of parkinsonism/Parkinson-plus syndromes;
- Features suggestive of other causes of dementia, including moderate to severe cerebrovascular disease by history, or imaging or history of major head trauma;
- History of deep brain stimulation, ablation surgery, or other brain surgery;
- Evidence for depression based on the Hospital Anxiety Depression Scale (score > 11).
Where it is running
- University Of Colorado. Denver, MEG Lab — Aurora, Colorado, United States
Full record on ClinicalTrials.gov
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