Procalcitonin Antibiotic Consensus Trial (ProACT)

Completed · Not applicable

Conditions studied: Lower Respiratory Tract Infection (LRTI)

In brief

The ProACT study is a 5 year, multicenter study that will test the effect of implementation of a novel procalcitonin guideline on antibiotic use and adverse outcomes in Emergency Department (ED) patients with Lower Respiratory Tract Infection (LRTI).

Key facts

Study ID

NCT02130986

Run by

University of Pittsburgh

People needed

1664

Starts

2014-11-03

Expected to finish

2017-07-21

Last updated by the study team

2019-01-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• ≥ 18 years old
• A primary clinical diagnosis in the ED of acute LRTI (< 28 days duration)
• Clinician willing to consider procalcitonin in antibiotic decision-making

You may not qualify if…

• Systemic antibiotics before ED presentation (All prophylactic antibiotic regimens, OR received >1 dose within 72 hours prior to ED presentation)
• Current vasopressor use
• Mechanical ventilation (via endotracheal tube)
• Known severe immunosuppression
• Accompanying non-respiratory infections
• Known lung abscess or empyema
• Chronic dialysis
• Metastatic cancer
• Surgery in the past 7 days (excluding minor surgery such as skin biopsy)
• Incarcerated or homeless
• Enrolled in ProACT in the past 30 days

Where it is running

• University of Alabama at Birmingham — Birmingham, Alabama, United States
• Maricopa Medical Center — Phoenix, Arizona, United States
• University of California at Irvine Medical Center — Orange, California, United States
• Norwalk Hospital — Norwalk, Connecticut, United States
• University of Maryland/Baltimore — Baltimore, Maryland, United States
• Massachusetts General Hospital — Boston, Massachusetts, United States
• Brigham and Women's Hospital — Boston, Massachusetts, United States
• Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States
• Wayne State University/Detroit Receiving Hospital — Detroit, Michigan, United States
• Essentia Institute of Rural Health — Duluth, Minnesota, United States
• The Ohio State University, College of Medicine — Columbus, Ohio, United States
• Penn State Hershey College of Medicine; Milton S. Hershey Medical Center — Hershey, Pennsylvania, United States
• University of Pittsburgh Medical Center — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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