Comparison of Outcomes During MRI Sedation With Midazolam-dexmedetomidine Versus Ketamine-dexmedetomidine

Stopped early · Not applicable

Conditions studied: Sedation

In brief

This study will compare 2 different sedation drugs (Ketamine and Midazolam) when they are used with another sedating medicine called Dexmedetomidine for MRI sedation. This study hopes to measure the impact each drug has on what happens during and after MRI sedation with Dexmedetomidine

Key facts

Study ID

NCT02129426

Run by

University of Louisville

People needed

21

Starts

2014-08-01

Expected to finish

2018-03-01

Last updated by the study team

2021-07-14

Who can join

Age: any, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Inpatient at Kosair Children's Hospital.
• Order placed by treating team for MRI of the brain with sedation.
• Age less than or equal to 18 years.
• Plan to sedate with dexmedetomidine, regardless of study participation.

You may not qualify if…

• Previous adverse reaction to dexmedetomidine or clonidine
• Current use of clonidine as a routine medication
• Concurrent use of a heart-rate decreasing medication (digoxin, propranolol)
• Contraindication to ketamine use
• Intracranial hypertension or traumatic brain injury
• Intraocular hypertension of eye trauma
• Pulmonary hypertension requiring medical management
• Planned additional procedure during the sedation encounter (non-brain MRI, lumbar puncture, EEG etc)

Where it is running

• University of Louisville — Louisville, Kentucky, United States

Full record on ClinicalTrials.gov

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