Effect of Cenicriviroc on HIV Neurocognitive Impairment

Completed · Phase 2

Conditions studied: AIDS Dementia Complex, HIV-1-Associated Cognitive Motor Complex, Human Immunodeficiency Virus

In brief

The study hypothesis is that cenicriviroc will improve cognition in HIV infected individuals with cognitive impairment. The investigators will study the effect of cenicriviroc on cognition in 24 subjects over a 24 week period.

Key facts

Study ID

NCT02128828

Run by

University of Hawaii

People needed

20

Starts

2014-04-01

Expected to finish

2016-06-01

Last updated by the study team

2020-08-20

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 4.2.1.1 Documentation of HIV-1 infection by an FDA approved test at any time prior to study entry
• On ARV medication uninterrupted for > 1 year leading up to the screening period
• Screening plasma HIV RNA < 50 copies/ml within 3 months of entry
• Willingness for males and females of childbearing potential to utilize 2 effective contraception methods (2 separate forms, one of which must be an effective barrier method), be non-heterosexually active or have a an exclusive vasectomized partner from screening throughout the duration of the study treatment and for 30 days following the last dose of study drugs.
• Age 18 to 70 years
• Ability and willingness to provide written informed consent
• Mild to moderate cognitive impairment with global neuropsychological (NP) test (NPZglobal) score of < -0.5 or a neurocognitive abnormality (<-0.5) in at least one cognitive domain known to be typically affected by HIV OR unimpaired
• On antiretroviral (ARV) therapy consisting of nucleoside reverse transcriptase inhibitors, atazanavir with/or without ritonavir, darunavir plus ritonavir, dolutegravir, raltegravir or efavirenz.

You may not qualify if…

• Receiving or used a CCR5 antagonist within 6 months of study entry
• Plasma HIV RNA > 100 copies/ml within 6 mo. of screening
• HIV-2
• Chronic hepatitis B (positive hepatitis B surface antigen)
• Chronic hepatitis C (positive hepatitis C antibody), except with proof of viral clearance and normal liver function tests
• Active or chronic liver disease
• Active or inadequately treated tuberculosis infection, or inadequate treatment for a positive purified protein derivative test. Adequate treatment meets current recommendations of the Center for Disease Control, NIH and the HIV Medicine Association of the Infectious Diseases Society of America (IDSA) guidelines or other Center for Disease Control recommendations if patient was treated before the current recommendations or before coinfection with HIV.
• Prior/current diagnosis with other intracellular pathogens (Listeria monocytogenes, Toxoplasma gondii, and Cryptococcus neoformans).
• Uncontrolled seizures
• Current or past malignancies excluding basal cell cancer and Kaposi's sarcoma (skin).
• Immunomodulator, HIV vaccine, any other vaccine, or investigational therapy within 30 days of entry.
• Requirement for acute therapy for AIDS-defining or other serious medical illnesses within 14 days of entry.
• Other chronic illnesses including hematologic, pulmonary, autoimmune diseases and endocrinopathies, except for stable controlled diabetes or cardiovascular disease in the view of the investigator and stable testosterone or thyroid therapy.
• Known hypersensitivity to CVC or its excipients
• Anticipated need for prescription medication not allowed in the study. Unwilling to stop eating grapefruit or using St. John's wort).
• Chronic use of over the counter medications unless approved by Study Investigator
• Hemoglobin < 8.5; Absolute neutrophil count < 1000; Platelet count < 100,000; serum glutamate oxaloacetate and pyruvate transaminase > 2.5x upper limit of normal ; Lipase > 2.0 x upper limit of normal
• Estimated creatinine clearance < 30 mL/min(Cockcroft and Gault 1979)
• Bradycardia, sinus rhythm <50 beats/min (bpm).
• Presence of any condition that would interfere with the absorption, distribution, metabolism, or excretion of the drug
• Current active illicit substance or alcohol use or abuse which, in the judgment of the Investigator, will interfere with the patient's ability to comply with protocol requirements
• Pregnancy or breast-feeding
• History of moderate (Child-Pugh class B) or severe (Child-Pugh C) hepatic impairment
• Patients, who, in the opinion of the Investigator, are unable to comply with the dosing schedule and protocol evaluation or for whom the study may not be advisable
• For MRI substudy [impaired]: Any factor that precludes MRI scan including presence of metal or exposure to metal work (e.g. metal grinder/worker) and claustrophobia

Where it is running

• Clint Spencer Clinic — Honolulu, Hawaii, United States

Full record on ClinicalTrials.gov

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