Resistance to Antibiotics in Patients Receiving Eye Injections

Completed

Conditions studied: Age-Related Macular Degeneration, Retinal Vein Occlusion, Diabetic Retinopathy

In brief

The administration of short courses of topical antibiotic drops before and/or after intravitreal injections is a common practice, but increasing evidence suggests this may not lower the risk of infectious endophthalmitis and could increase rates of antimicrobial resistance. The purpose of the present study is to determine the antimicrobial resistance profiles in patients who have received numerous (≥ 20) courses of antibiotics for intravitreal injection compared with untreated controls. This study compares 20 control patients without prior intravitreal injection to 20 patients who have undergone ≥ 20 prior intravitreal injections accompanied by a course of topical antibiotics for two days before and/or after the injection procedure. The lower, inner eyelid and nasal cavity were cultured and evaluated via disk diffusion method for antimicrobial sensitivity.

Key facts

Study ID

NCT02126423

Run by

Prism Vision Group

People needed

40

Starts

2014-05-01

Expected to finish

2014-09-01

Last updated by the study team

2016-06-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients (above age 18) diagnosed with age-related macular degeneration and receiving their 1st or 20th (or >20th) intravitreal injection therapy.

You may not qualify if…

• Those with current use of topical or systemic antibiotics and an active ocular infection or ocular surface disease.

Where it is running

• NJ Retina — Edison, New Jersey, United States

Full record on ClinicalTrials.gov

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