A Trial of Surgery and Fractionated Re-Irradiation for Recurrent Ependymoma

Running, not enrolling · Phase 2

Conditions studied: Ependymoma

In brief

The primary purpose of this study is to investigate whether surgery and re-irradiation will help treat ependymoma that has come back after initial treatment. The combined doses of the first and second courses of radiation are higher than what is usual standard of care. The investigators will study the effects and side effects of surgery and re-irradiation. They will also evaluate and study tumor tissue and blood to learn more about the tumor and how it does or does not respond to treatments and will use magnetic resonance imaging (MRI) and positron emission tomography (PET) scans to see if they can predict tumor response and tumor recurrence. Participants will be followed for up to 5 years following enrollment. Evaluations during radiation therapy will be done weekly while receiving therapy for up to 7 weeks. Other evaluations will be done at enrollment, every 4 months from enrollment through 3 years, and every 6 months during the 4th and 5th year.

Key facts

Study ID

NCT02125786

Run by

St. Jude Children's Research Hospital

People needed

68

Starts

2014-05-07

Expected to finish

2028-05-01

Last updated by the study team

2026-02-24

Who can join

Age: 1 and older, up to 21. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Progressive intracranial ependymoma after prior focal irradiation
• Patients aged 1-21 years at the time of enrollment
• Adequate performance status (ECOG < 3) and research participant does not require mechanical ventilation
• Interval from start of initial radiation therapy to enrollment > 9 months

You may not qualify if…

• Prior craniospinal irradiation
• Pregnant women are excluded from enrollment on this study because radiation therapy is an agent with the potential for teratogenic or abortifacient effects
• Any patient with both metastatic ependymoma and age < 3 years at the time of enrollment

Where it is running

• St. Jude Children's Research Hospital — Memphis, Tennessee, United States

Full record on ClinicalTrials.gov

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