EIMD Mechanisms Causing Force Loss

Stopped early · Phase 1 · Has a placebo group

Conditions studied: Healthy

In brief

We have hypothesized: 1) Caffeine will increase maximal voluntary strength compared to placebo in undamaged muscle. 2) Caffeine will increase muscle activation compared to placebo in undamaged muscle. 3) Caffeine will enhance spinal excitability (indicated by an enhanced H-reflex) compared to placebo in undamaged muscle. 4) Caffeine will raise the pressure-pain threshold (indicating decreased pain sensitivity) in the calf muscle compared to placebo in undamaged muscle. 5) Caffeine will reduce the amount of low-frequency fatigue, indicated by an enhanced 20-100 hertz strength ratio, compared to placebo in undamaged muscle. 6) Caffeine will increase maximal voluntary strength compared to placebo in damaged muscle. 7) Caffeine will increase muscle activation compared to placebo in damaged muscle. 8) Caffeine will enhance spinal excitability (indicated by an enhanced H-reflex) compared to placebo in damaged muscle. 9) Caffeine will raise the pressure-pain threshold (indicating decreased pain sensitivity) in the calf muscle compared to placebo in damaged muscle. 10) Caffeine will reduce the amount of low-frequency fatigue, indicated by an enhanced 20-100 hertz strength ratio, compared to placebo in damaged muscle. The proposed research will determine the effects of a 5mg/kg body weight dose of caffeine on muscular strength, activation, H-reflex function, and excitation-contraction coupling before and after exercise-induced muscle damage. The long term objectives are to gain a better understanding of caffeine and its affects following exercise-induced muscle damage allowing us to understand how caffeine is mechanistically interacting with functions of the body.

Key facts

Study ID

NCT02125643

Run by

University of Oklahoma

People needed

3

Starts

2014-08-01

Expected to finish

2015-05-01

Last updated by the study team

2017-06-05

Who can join

Age: 18 and older, up to 35. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• age range of 18-35 years of age
• males and females who do not have a history of orthopedic injuries of the hip knee, and/or leg
• Participants must be engaged in some form of physical activity on at least 3 days each week

You may not qualify if…

• An answer of "yes" to any of the seven questions on the physical activity readiness questionnaire (PAR-Q)
• Average daily consumption of more than 40mg of caffeine per day as determined by the 2 week caffeine recall questionnaire
• Use of any type of prescription psychiatric or prescription or over-the-counter pain medication
• An answer of "yes" to questions 1,2,8, and 15-22 on the rhabdomyolysis screening questionnaire
• An answer of "yes" on questions 3,4,6,7,8, 11,12, and 13 if the follow up information indicates any type of medication, drug, supplement, illness, and/or dietary need that could affect pain sensitivity or the risk of dehydration. Determinations will be made on a participant-by-participant basis depending on the answers provided
• An answer of "yes" on question 24 indicating a previous adverse reaction to caffeine consumption
• Resting systolic blood pressure >140 mmHg and/or resting diastolic blood pressure >90 mmHg
• Pregnancy or suspicion of pregnancy.

Where it is running

• Sensory and Muscle Function Lab 7 — Norman, Oklahoma, United States

Full record on ClinicalTrials.gov

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