Vidaza and Valproic Acid Post Allogeneic Transplant for High Risk AML and MDS

Status unconfirmed · Phase 2

Conditions studied: Acute Myelogenous Leukemia AML, Myelodysplastic Syndrome MDS

In brief

Phase II trial combining azacitidine with valproic acid as maintenance therapy post allogeneic stem cell transplantation in patients with high-risk MDS/AML. We hypothesize that adding valproic acid to azacitidine will improve outcomes via both direct anti-tumor and immunologically mediated antitumor response with alloreactive donor lymphocytes, having an additive effect and extending 1 year survival in patient with high-risk AML/MDS after hematopoietic stem cell transplant. Based on aforementioned data from the US Department of Health and Human Services, standard 1 year survival for AML after stem cell transplant is near 40%. We hypothesize that valproic acid and azacitidine will prolong survival, with a 1 year survival goal of 60%. In addition to assessing for 1 year survival, we will have secondary objectives of assessing progression-free survival, relapse, and toxicity. The primary toxicity endpoint from this will be cytopenias and infections.

Key facts

Study ID: NCT02124174
Run by: Patrick Stiff
People needed: 50
Starts: 2012-01-01
Expected to finish: 2022-01-01
Last updated by the study team: 2021-04-26

Who can join

Age: 2 and older, up to 89. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

All allograft patients > 2 years of age.
Patients will have one of the following malignancies:
a. Patients with refractory or relapsed: acute myelogenous leukemia (AML) (including inv16, t(8;21) or t(15;17)) or high risk myelodysplastic syndrome (MDS) (defined as bone marrow blasts > or = 5%) are eligible. Patients may be in remission at the time of entry.
Patients with adequate organ function and performance status criteria measured by:
Karnofsky score greater than or equal to 70% or Performance status of < or = 2 by the Eastern Cooperative Oncology Group (ECOG) scale
Adequate liver function (bilirubin of < 2mg/dL, serum glutamate pyruvate transaminase < 3 * ULN) and renal function (creatinine < 2mg/dL)
Signed informed consent indicating that patients are aware of the investigational nature of this study in accordance with the regulations of Loyola University Medical Center
Patients must have undergone allogeneic stem cell transplant within 40-60 days before starting treatment and be self-sufficient in caloric intake along with no active graft vs. host disease

You may not qualify if…

Nursing and pregnant females are excluded.
Active and uncontrolled infections will cause patients to be excluded.
Patients already receiving valproic acid or receiving other anticonvulsants will be excluded.
Low risk AML in complete remission 1, will not be candidates for this study.
Patients with an absolute neutrophil count less than 1500 will be excluded
Patients with platelets less than 50,000 will be excluded
Children less than 2 years of age will be excluded due to increased hepatotoxicity from valproic acid in this age group

Where it is running

Loyola University Cardinal Bernardin Cancer Center — Maywood, Illinois, United States (enrolling)

Full record on ClinicalTrials.gov

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