Study to Assess Dopamine Receptor Modulation With Rotigotine to Enhance Morphine Analgesia in the Dental Model

Status unconfirmed · Phase 2 · Has a placebo group

Conditions studied: Post-op Pain

In brief

Narcotics are widely used as the mainstay of pain treatment, although increasing doses are required over time as the individual becomes tolerant to their effects. This can lead to the development of dependence and abuse of these drugs. Research has identified a new way to decrease the risk of developing tolerance to narcotics, by giving at the same time a drug called rotigotine ("Neupro"). Rotigotine interferes with the body's chemical dopamine and is FDA-approved for the management of Parkinson's Disease. The purpose of this research study is to look at side effects and pain control in healthy people after removal of wisdom teeth, which usually causes pain. It is thought that by giving the study drug rotigotine with the narcotic pain reliever, there will be pain control that will extend longer than when giving the narcotic alone.

Key facts

Study ID

NCT02123979

Run by

East Carolina University

People needed

50

Starts

2015-11-01

Expected to finish

2017-01-01

Last updated by the study team

2015-08-07

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• • Male and female patients aged 18 and over scheduled to undergo elective oral surgery for the removal of impacted third molars
• Indicated for the removal of 3-4 third molars, at least two of which are categorized as partial-boney or full-boney impactions
• Self-report of moderate or severe pain on a categorical scale with a minimum of 5 out of 10 on the numerical rating scale following the offset of local anesthesia

You may not qualify if…

• History or intolerance to rotigotine
• Current or history of mental disorder or substance abuse
• Allergy or intolerance to opioids or local anesthetics
• Concurrent or recent use of agents that may confound the sedative effects of the study drug (opioids, benzodiazepines) over the previous 7 days or alcohol ingestion in the previous 24 hours
• Chronic or recent use of medications that might confound the effects of rotigotine, e.g., antihistamines, prescription or over-the-counter NSAIDs, acetaminophen, steroids, antidepressants, muscle relaxants.
• Concurrent or history of chronic diseases, e.g., diabetes, rheumatoid arthritis, liver disease, cancer, hypertension or obesity (body mass index >35).

Where it is running

• School of Dental Medicine At East Carolina University — Greenville, North Carolina, United States

Full record on ClinicalTrials.gov

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