A Study Of PF-06664178 In Patients With Advanced Solid Tumors

Stopped early · Phase 1

Conditions studied: Neoplasms

In brief

To assess the safety and tolerability at increasing dose levels of PF-06664178 in patients with advanced solid tumors in order to determine the maximum tolerated dose and select the recommended Phase 2 dose.

Key facts

Study ID

NCT02122146

Run by

Pfizer

People needed

31

Starts

2014-08-01

Expected to finish

2016-06-01

Last updated by the study team

2018-02-19

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of solid tumor that is advanced/metastatic and resistant to standard therapy or for whom no standard therapy is available
• Performance Status of 0 or 1
• Adequate bone marrow, kidney and liver function
• Part 2 includes target expressing NSCLC, ovarian or breast cancer patients

You may not qualify if…

• Brain metastases requiring steroids
• Major surgery, radiation therapy, or systemic anti-cancer therapy within 4 weeks of study treatment start (6 weeks for mitomycin C or nitrosoureas)
• Active and clinically significant bacterial, fungal, or viral infection

Where it is running

• Keck Hospital of USC — Los Angeles, California, United States
• LAC&USC Medical Center — Los Angeles, California, United States
• USC/Norris Comprehensive Cancer Center / Investigational Drug Services — Los Angeles, California, United States
• USC/Norris Comprehensive Cancer Center — Los Angeles, California, United States
• Anschutz Cancer Pavilion — Aurora, Colorado, United States
• University of Colorado Denver CTO (CTRC) — Aurora, Colorado, United States
• University of Colorado Hospital — Aurora, Colorado, United States
• Swedish Medical Center — Seattle, Washington, United States
• Seattle Cancer Care Alliance — Seattle, Washington, United States
• University of Washington Medical Center — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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