Florbetapir Calibration to the Centiloid Scale
Completed · Phase 1
Conditions studied: Alzheimer's Disease
In brief
This study is designed to demonstrate the conversion of florbetapir (18F) Positron Emission Tomography (PET) Standard Uptake Value ratio (SUVr) to Centiloid units.
Key facts
- Study ID
- NCT02120664
- Run by
- Avid Radiopharmaceuticals
- People needed
- 35
- Starts
- 2014-04-01
- Expected to finish
- 2015-09-01
- Last updated by the study team
- 2017-03-09
Who can join
Age: 21 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Cognitively Normal Subjects
- Males or females ≥ 21 and ≤ 45 years of age
- Mini-mental state examination (MMSE) ≥ 29
- Clinically Diagnosed AD Subject
- Males or females ≥ 50 years of age
- Meet clinical criteria for dementia due to probable AD
- MMSE ≥ 16 and ≤ 26
- Possible AD Subject
- Males or females ≥ 50 years of age
- Meet clinical criteria for dementia due to possible AD
- MMSE ≥ 16 and ≤ 26
- MCI Subject
- Males or females ≥ 60 years of age with cognitive impairment (not dementia)
- MMSE >24 and <29
- At Risk Elderly Subject
- Cognitively normal males or females that are known ApoE4 carriers and ≥ 75 years of age
- MMSE ≥ 27
You may not qualify if…
- Have had or currently have a diagnosis of neurodegenerative disorders other than AD
- Have a current serious or unstable illness that could interfere with completion of the study
- Subject has a known brain lesion, pathology or traumatic brain injury
- Have received or participated in a trial with investigational medications in the past 30 days
- Have had a radiopharmaceutical imaging or treatment procedure within 7 days of study imaging session
- Females of childbearing potential who are not surgically sterile, not refraining from sexual activity or not using reliable methods of contraception
Where it is running
- Research Site — Pittsburgh, Pennsylvania, United States
- Research Site — Heidelberg, Victoria, Australia
Full record on ClinicalTrials.gov
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